| Empirical Formula (Hill Notation): | C18H36N4O11 · H2O4S |
| CAS Number: | 25389-94-0 |
| Molecular Weight: | 582.58 |
| EC Number: | 246-933-9 |
| MDL number: | MFCD00070253 |
| PubChem Substance ID: | 329823411 |
| NACRES: | NA.24 |
| Кат. номер |
| PHR1487-500MG |
| PHR1487-500MG-PW |
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Kanamycin Sulfate, generated by specific strains of
Streptomyces kanamyceticus, belongs to the class of aminoglycoside antibiotics. It is known to act effectively against a broad spectrum of Gram-negative and Gram-positive bacteria.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Kanamycin Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.
Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.
Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
This Certified Reference Material (CRM) is produced and certified in accordance with
ISO 17034 and
ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7808 in the slot below. This is an example certificate only and may not be the lot that you receive.
| Quality Level | 300 |
| grade | certified reference material, pharmaceutical secondary standard |
| CofA | current certificate can be downloaded |
| packaging | pkg of 500 mg |
| application(s) | HPLC: suitable, gas chromatography (GC): suitable |
| Featured Industry | Pharmaceutical (small molecule) |
| format | neat |
| pharmacopeia traceability | traceable to BP 861, traceable to PhEur K0200000, traceable to USP 1355006 |
| SMILES string | OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O |
| InChI | 1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1 |
| InChI key | OOYGSFOGFJDDHP-KMCOLRRFSA-N |
| pictograms | GHS08 |
| signalword | Danger |
| hcodes | H360 |
| pcodes | P201 - P308 + P313 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point F | Not applicable |
| Flash Point C | Not applicable |