Isotretinoin

Empirical Formula (Hill Notation):	C20H28O2
CAS Number:	4759-48-2
Molecular Weight:	300.44
EC Number:	225-296-0
MDL number:	MFCD00079542
PubChem Substance ID:	329823198
NACRES:	NA.24

Кат. номер

PHR1188-3X100MG-PW

PHR1188-100MG-PW

PHR1188-3X100MG

Isotretinoin is a vitamin A derivative, obtained from the isomerization of retinoic acid in the body. It is therapeutically used to treat severe recalcitrant nodular acne. It is also reported to exhibit anti-inflammatory and anti-tumor activities.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Isotretinoin may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography.
13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action. The action of RA is mediated through RAR- and RAR- receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0144 in the slot below. This is an example certificate only and may not be the lot that you receive.

Quality Level	300
grade	certified reference material, pharmaceutical secondary standard
form	neat
CofA	current certificate can be downloaded
application(s)	HPLC: suitable, gas chromatography (GC): suitable
mp	172-175 °C (lit.)
Featured Industry	Pharmaceutical (small molecule)
format	neat
pharmacopeia traceability	traceable to PhEur I0800000, traceable to USP 1353500
SMILES string	[H]\C(C(O)=O)=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C
InChI	1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-
InChI key	SHGAZHPCJJPHSC-XFYACQKRSA-N
Gene Information	human ... RARA(5914), RARB(5915), RARG(5916)

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H315 - H319 - H335 - H360
pcodes	P201 - P202 - P261 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Target Organs	Respiratory system
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3