(S,R,S)-AHPC hydrochloride 901490-100MG

Empirical Formula (Hill Notation):	C22H30N4O3S · xHCl
CAS Number:	1448189-80-7
Molecular Weight:	430.56 (free base basis)
MDL number:	MFCD30502992

(S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487,) used as a negative control.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation,
Portal: Building PROTAC® Degraders for Targeted Protein Degradation,
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities,
Modular PROTAC Design for the DegradationofOncogenic BCR-ABL,
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4,
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298),
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Quality Level	100,
assay	97%
form	powder or crystals
storage temp.	2-8°C
SMILES string	N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl, N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable