2,6-Di-tert-butyl-4-methylphenol
| Empirical Formula (Hill Notation): | C15H24O |
| Linear Formula: | [(CH3)3C]2C6H2(CH3)OH |
| CAS Number: | 128-37-0 |
| Molecular Weight: | 220.35 |
| Beilstein/REAXYS Number: | 1911640 |
| EC Number: | 204-881-4 |
| MDL number: | MFCD00011644 |
| PubChem Substance ID: | 57653920 |
| NACRES: | NA.22 |
| Кат. номер |
| B1378-100G |
| B1378-500G |
| B1378-1KG |
1 kg in poly bottle
100, 500 g in poly bottle
Butylated hydroxytoluene (BHT) is a phenolic antioxidant. It has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-
tert-butyl-2-[2-(2-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF- which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1.
| vapor density | 7.6 (vs air) |
| Quality Level | 200 |
| vapor pressure | <0.01 mmHg ( 20 °C) |
| assay | 99.0% (GC) |
| form | powder |
| autoignition temp. | 878 °F |
| bp | 265 °C (lit.) |
| mp | 69-73 °C (lit.) |
| solubility | ethanol: 100 mg/mL, vegetable oils: soluble |
| SMILES string | Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C |
| InChI | 1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3 |
| InChI key | NLZUEZXRPGMBCV-UHFFFAOYSA-N |
| Gene Information | human ... CAPN1(823) rat ... Capn1(29153), Nos1(24598) |
| Pictograms | GHS09 |
| Signal Word | Warning |
| Hazard Statements | H410 |
| Precautionary Statements | P273 - P391 - P501 |
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 2 |
| Flash Point(F) | 260.6 °F - open cup |
| Flash Point(C) | 127 °C - open cup |