Mycophenolic acid

Empirical Formula (Hill Notation):	C17H20O6
CAS Number:	24280-93-1
Molecular Weight:	320.34
Beilstein/REAXYS Number:	1295848
EC Number:	246-119-3
MDL number:	MFCD00036814
PubChem Substance ID:	329769720
NACRES:	NA.24

Кат. номер

89287-VAR

89287-10MG

Mycophenolic acid is an active metabolite of the ester prodrug mycophenolate mofetil (MPM), which is prescribed as an immunosuppressant to prevent the organ transplantation rejection and also in the treatment of certain autoimmune diseases.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25µg/mL.
Mycophenolic acid may be used as a reference standard for the determination of the analyte in human plasma by ultra-performance liquid chromatography tandem mass spectrometry.
Mode of Action: This product acts by suppressing the cytokine-induced nitric oxide production, inhibiting early stage biosynthesis of purine nucleotides and as a specific inhibitor of IMP dehydrogenase.
As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly.
Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C.

Quality Level	100
grade	analytical standard
assay	98.5% (HPLC)
form	neat
shelf life	limited shelf life, expiry date on the label
application(s)	HPLC: suitable, gas chromatography (GC): suitable
impurities	1.0% water
Featured Industry	Forensics and Toxicology Pharmaceutical (small molecule)
format	neat
storage temp.	2-8°C
SMILES string	COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
InChI	1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
InChI key	HPNSFSBZBAHARI-RUDMXATFSA-N
Gene Information	human ... IMPDH1(3614), IMPDH2(3615)

pictograms	GHS07,GHS08,GHS09
signalword	Danger
hcodes	H302 - H341 - H360D - H372 - H410
pcodes	P201 - P273 - P301 + P312 + P330 - P308 + P313
Target Organs	Immune system
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable