m-Chloramphenicol

Empirical Formula (Hill Notation):	C11H12Cl2N2O5
CAS Number:	7411-65-6
Molecular Weight:	323.13
MDL number:	MFCD07370152
PubChem Substance ID:	329754750

Кат. номер

34005-10MG-R

34005-100MG-R

34005-VAR-R

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.
Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.
Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
Stock solutions should be stored at 2-8°C and are stable at 37°C for 5 days. Aqueous solutions are neutral and stable over a wide pH range, with 50% hydrolysis occurring after 290 days. Use of a borax buffered solution reduces this number to 14%. Solutions should be protected from light as photochemical decomposition results in a yellowing of the solution. Heating aqueous solutions at 115°C for 30 minutes results in a 10% loss of chloramphenicol.
Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.
VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Quality Level	100
grade	analytical standard
description	threo-form
product line	VETRANAL®
form	neat
shelf life	limited shelf life, expiry date on the label
application(s)	HPLC: suitable, gas chromatography (GC): suitable, solid phase extraction (SPE): suitable
Featured Industry	Forensics and Toxicology Pharmaceutical (small molecule)
format	neat
storage temp.	2-8°C
SMILES string	OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1cccc(c1)[N+]([O-])=O
InChI	1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-2-1-3-7(4-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChI key	FTMJFHVKAXPFIY-RKDXNWHRSA-N

pictograms	GHS08
signalword	Danger
hcodes	H350
pcodes	P201 - P202 - P280 - P308 + P313 - P405 - P501
Personal Protective Equipment	Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3