Acetic anhydride

Empirical Formula (Hill Notation):	C4H6O3
Linear Formula:	(CH3CO)2O
CAS Number:	108-24-7
Molecular Weight:	102.09
Beilstein/REAXYS Number:	385737
EC Number:	203-564-8
MDL number:	MFCD00008705
PubChem Substance ID:	329770002
NACRES:	NA.22

Кат. номер

91204-10ML-F

91204-25ML-F

91204-1ML-F

91204-VAR-F

91204-10X1ML-F

91204-VAR

Acetic anhydride is an esterification agent which is corrosive to metals. It is a colourless liquid with strong vinegar-like odour. It is mostly used in making plastics, fibers, pharmaceuticals, dyes and explosives.
Acylation, an alternative to silylation, enables the conversion of compounds that comprise of active hydrogens (-OH, -SH and -NH) into esters, thioesters, and amides by the action of a carboxylic acid or derivative. The carbonyl group adjacent to the halogenated carbons favors the improvement of electron capture detector (ECD) response. Acylation has several benefits:

• It increases the stability of compounds by protecting unstable groups.
• It may render volatility on substances like carbohydrates or amino acids, that have several polar groups that they are non-volatile and generally decompose on heating.
• It allows the separations not possible with underivatized compounds.
• Compounds are detectable at very low levels with an ECD.

Acetic anhydride is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis.
Suitable for the derivatization of acetyl, acetaminophen, alcohols, aldoses and partially methylated aldoses, aldosterone, amines, amino acids, amino sugars (in polysaccharides), amino sugar methyl glycosides, 2-amino-2-deoxyhexoses, arginyl peptides, aryl sulfate esters, bile acids, carbamates, carbohydrates, cerebrosides, cystine and cysteine (in peptides), desmethyldoxepin, 3,4-dihydroxyphenylglycol, estrogens, glycitols, hexopyranosides, hexosamines, hydroxamic acids, hydroxyamines, n-hydroxycarbamates, hydroxy steroids, inositols, 4-methoxy and 3,4-dimethoxyphenethylamine, methyl ester, methyl(methyl O-methyl-a-D-glucopyranosid)uronates, nucleosides, nucleoside bases and sugars, partially methylated pentose and hexoes, peptides, phenolalkylamines, phenylethylamines, polysaccharide constituents, postaglandins A,B and E, serotonin, sialic acids, sugars, natural sugars and tryptamine.
Learn more in the Product Information
10×1 mL in glass insert
Reagent for acetic anhydride, acetyl, n-acetyl, n-acetyl-n, o-acetyl, acetate, aldononitrile acetate, aminoglycitol acetate, aryl acetate, permethyl acetyl, methyl ester, trifluoroacetyl, bis-trimethylsilyl, trimethylsilyl polyamino alcohol, and O-trimethylsilyl (TMS).
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Quality Level	100
grade	for GC derivatization
vapor density	3.5 (vs air)
vapor pressure	10 mmHg ( 36 °C), 4 mmHg ( 20 °C)
assay	99.0% (GC), 99.0%
autoignition temp.	629 °F
quality	LiChropur™
expl. lim.	10.3 %
reaction suitability	reagent type: derivatization reagent reaction type: Acylations
application(s)	gas chromatography (GC): suitable
evapn. residue	0.003%
refractive index	n20/D 1.390 (lit.)
bp	138-140 °C (lit.)
mp	73 °C (lit.)
solubility	H2O: slightly soluble
density	1.08 g/mL (lit.)
SMILES string	CC(=O)OC(C)=O
InChI	1S/C4H6O3/c1-3(5)7-4(2)6/h1-2H3
InChI key	WFDIJRYMOXRFFG-UHFFFAOYSA-N

pictograms	GHS02,GHS05,GHS06
signalword	Danger
hcodes	H226 - H302 - H314 - H330
pcodes	P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
Supp Hazards	EUH071
Personal Protective Equipment	Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
RIDADR	UN 1715 3(8) / PGII
WGK Germany	WGK 1
Flash Point F	120.2 °F - closed cup
Flash Point C	49 °C - closed cup