Famciclovir
| Empirical Formula (Hill Notation): | C14H19N5O4 |
| CAS Number: | 104227-87-4 |
| Molecular Weight: | 321.33 |
| MDL number: | MFCD00866964 |
| PubChem Substance ID: | 329823560 |
| NACRES: | NA.24 |
| Кат. номер |
| PHR1696-1G |
| PHR1696-1G-PW |
Famciclovir is an antiviral drug, which is predominantly used in the treatment of herpes virus infection. It is an inactive prodrug, which on administration, undergoes rapid biotransformation to penciclovir.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Famciclovir may be used as a reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by spectrophotometry and high performance liquid chromatography.
Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
This Certified Reference Material (CRM) is produced and certified in accordance with
ISO 17034 and
ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3254 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
| Quality Level | 300 |
| grade | certified reference material, pharmaceutical secondary standard |
| CofA | current certificate can be downloaded |
| packaging | pkg of 1 g |
| application(s) | HPLC: suitable, gas chromatography (GC): suitable |
| Featured Industry | Pharmaceutical (small molecule) |
| format | neat |
| pharmacopeia traceability | traceable to USP 1269152 |
| SMILES string | CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(C)=O |
| InChI | 1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18) |
| InChI key | GGXKWVWZWMLJEH-UHFFFAOYSA-N |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point F | Not applicable |
| Flash Point C | Not applicable |