Propyl gallate

Empirical Formula (Hill Notation):	C10H12O5
Linear Formula:	3,4,5-(HO)3C6H2CO2CH2CH2CH3
CAS Number:	121-79-9
Molecular Weight:	212.20
Beilstein/REAXYS Number:	1877976
EC Number:	204-498-2
MDL number:	MFCD00002196
PubChem Substance ID:	329823139
E Number:	E310
NACRES:	NA.24

Кат. номер

PHR1118-1G

PHR1118-1G-PW

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Propyl gallate is a synthetic phenolic antioxidant (SPA) utilized in food additives to inhibit or regulate the lipid oxidation. SPAs are cost-effective, largely available and highly efficient in comparison to their natural counterparts.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Propyl gallate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and fatty liquids by chromatography and spectrophotometry.
Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 µM when it was combined with copper concentrations at 5 µM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.
Prepare a 0.1M solution in glycerol:PBS (9:1)
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8981 in the slot below. This is an example certificate only and may not be the lot that you receive.

Quality Level	300
grade	certified reference material, pharmaceutical secondary standard
form	neat
CofA	current certificate can be downloaded
application(s)	HPLC: suitable, gas chromatography (GC): suitable
mp	146-149 °C (lit.)
Featured Industry	Cleaning Products Cosmetics Flavors and Fragrances Food and Beverages Personal Care Pharmaceutical (small molecule)
format	neat
pharmacopeia traceability	traceable to PhEur P3640000, traceable to USP 1576800
SMILES string	CCCOC(=O)c1cc(O)c(O)c(O)c1
InChI	1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3
InChI key	ZTHYODDOHIVTJV-UHFFFAOYSA-N

pictograms	GHS05,GHS07,GHS09,GHS05,GHS07,GHS09
signalword	Danger-Danger
hcodes	H302 - H317 - H318 - H410 - H302 - H317 - H318 - H410
pcodes	P273 - P280 - P261 - P273 - P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310 - P301 + P312 - P302 + P352 - P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point F	368.6 °F - closed cup
Flash Point C	187 °C - closed cup