Cyclosporine

Empirical Formula (Hill Notation):	C62H111N11O12
CAS Number:	59865-13-3
Molecular Weight:	1202.61
Beilstein/REAXYS Number:	3647785
MDL number:	MFCD00274558
PubChem Substance ID:	329823114
NACRES:	NA.24

Кат. номер

PHR1092-500MG

PHR1092-500MG-PW

Cyclosporine is a lipophilic immunosuppressive peptide with antifungal and anti-inflammatory properties. It selectively inhibits the production of cytokines involved in T-lymphocyte activation in response to antigen stimulation. It is widely used to prevent transplanted organ rejection and for the treatment of various autoimmune diseases.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Cyclosporine may be used as a reference standard for the determination of cyclosporine in biological samples by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method.
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB3757 in the slot below. This is an example certificate only and may not be the lot that you receive.

Quality Level	300
grade	certified reference material, pharmaceutical secondary standard
form	neat
CofA	current certificate can be downloaded
application(s)	HPLC: suitable, gas chromatography (GC): suitable
Featured Industry	Pharmaceutical (small molecule)
format	neat
pharmacopeia traceability	traceable to PhEur C2163000, traceable to USP 1158504
SMILES string	CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InChI	1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
InChI key	PMATZTZNYRCHOR-CGLBZJNRSA-N
Gene Information	human ... PPIA(5478)

pictograms	GHS07,GHS08
signalword	Danger
hcodes	H302 - H350 - H360FD
pcodes	P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3