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SPITE Medium Supplement (100)
NACRES: NA.75
Кат. номер S5666-5ML S5666-PH ApplicationSerum-free and reduced serum formulations often require purified forms of the factors normally supplied by serum that are suitable for in vitro growth and differentiation studies. These important factors include insulin, transferrin, selenium, pyruvate, and ethanolamine.
INSULIN is a polypeptide hormone that promotes the uptake of glucose and amino acids and may owe observed mitogenic effect to this property.
TRANSFERRIN is an iron-transport protein. Iron is an essential trace element, but can be toxic in the free form. To nourish cells in culture, it is supplied bound to transferrin in serum.
SELENIUM is an essential trace element normally provided by Serum.
SODIUM PYRUVATE has been shown to be beneficial as an additional energy source in some instances.
ETHANOLAMINE is a fatty acid that plays a significant role in the proliferation of hybridoma cells and frequently is added to supplements used for culturing these cells.
Nutritional studies indicate that the supplement components described are utilized by most mammalian cells. They enhance cell proliferation and decrease the serum requirement of many cell types. When the provided supplement is used with 2 to 4 percent serum, proliferation is reported to be similar to medium supplemented with 10 percent serum.
For suspension cell culturesComponentsContains 1.0mg/ml recombinant human insulin, 0.55mg/ml human transferrin (substantially iron-free), 0.5μg/ml sodium selenite, 12mg/ml pyruvate and 0.2mg/ml ethanolamine at the 100x concentration.Other NotesSPITE is a mixture of recombinant human insulin, human transferrin (partially iron-saturated), sodium selenite, sodium pyruvate and ethanolamine. It is designed for cell cultures in which media without sodium pyruvate are used.Preparation NotePrepared in Earle′s Balanced Salt Solution (EBSS) without phenol red.ПараметрыQuality Level 400, sterility sterile-filtered product line BioReagent form liquid storage condition protect from light application(s) cell culture | mammalian: suitable impurities endotoxin, tested shipped in ambient storage temp. 2-8°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Tryptose Broth
NACRES: NA.75
Кат. номер T4532-1KG T4532-10KG T4532-250G T4532-100G ApplicationIn addition to its use for the growth of fastidious micro-organisms, Tryptose Phospate Broth (TPB) has been studied as supplement for the preparation of media that supports vaccine production in BHK-21 cells and the growth of SF21 insect cells in high-density perfusion culture stirred-tank bioreactors.Packaging250 g in poly bottle
1 kg in poly bottleComponentsTryptose Phosphate Broth (TPB) is composed of four components: Tryptose (20g/L); Dextrose (2g/L); NaCl (5g/L) and Disodium Phosphate (2.5g/L) typically adjusted to pH 7.3. The tryptose component is a peptone (mixture of amino acids and short peptides) derived by the mixed enzymatic hydrolysis (pancreatic enzymes) of the milk protein casein. This hydrolysate provides a source of amino acid based nutrients and survival factors that support the growth of fastidious micro-organisms such as Brucella, Streptococcus, and Neisseria; as well as eukaryotic cells such as insect and animal cells. Dextrose provides a fermentable carbohydrate that can be used by fastidious mico-organisms. Sodium chloride maintains the osmotic and ionic equilibrium and disodium phosphate provides the basic buffering capacity.Other NotesThis Tryptose broth is closely related to Tryptose phosphate broth, but does not contain the phosphate component and it contains a lower concentration of dextrose.Preparation NoteThis formulation contains Tryptose (20 g/L); Dextrose (1 g/L); and NaCl (5g/L) adjusted to a final pH of 7.2.Параметрыbiological source Porcine pancreas Quality Level 200, form liquid application(s) cell culture | insect: suitable shipped in ambient storage temp. 2-8°C
Safety InformationRIDADR NONH for all modes of transport WGK Germany nwg Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Tryptose Phosphate Broth
NACRES: NA.75
Кат. номер T8782-10KG T8782-500G T8782-1KG General descriptionThe tryptose component of Tryptose Phosphate Broth is a peptone (mixture of amino acids and short peptides) derived by the mixed enzymatic hydrolysis (pancreatic enzymes) of the milk protein casein.ApplicationTryptose Phosphate Broth has been used as a component:- of Leibovitz L-15 medium for the culture of BME26 tick embryo cell line
- of M199 medium for the preparation of chick embryo fibroblasts (CEFs)
- of Glasgows minimum essential medium (GMEM) for culturing baby hamster kidney (BHK-21) before transfection
In addition to its use for the growth of fastidious micro-organisms, Tryptose Phospate Broth (TPB) has been studied as supplement for the preparation of media that supports vaccine production in BHK-21 cells and the growth of SF21 insect cells in high-density perfusion culture stirred-tank bioreactors.Packaging500 g in poly bottle
1 kg in poly bottle
10 kg in poly drumBiochem/physiol ActionsTryptose Phosphate Broth provides a source of amino acid based nutrients and survival factors that support the growth of fastidious micro-organisms such as Brucella, Streptococcus, and Neisseria; as well as eukaryotic cells such as insect and animal cells. Dextrose provides a fermentable carbohydrate that can be used by fastidious micro-organisms. Sodium chloride maintains the osmotic and ionic equilibrium and disodium phosphate provides the basic buffering capacity.ComponentsTryptose Phosphate Broth (TPB) is composed of four components: Tryptose (20g/L); Dextrose (2g/L); NaCl (5g/L) and Disodium Phosphate (2.5g/L) typically adjusted to pH 7.3. The tryptose component is a peptone (mixture of amino acids and short peptides) derived by the mixed enzymatic hydrolysis (pancreatic enzymes) of the milk protein casein. This hydrolysate provides a source of amino acid based nutrients and survival factors that support the growth of fastidious micro-organisms such as Brucella, Streptococcus, and Neisseria; as well as eukaryotic cells such as insect and animal cells. Dextrose provides a fermentable carbohydrate that can be used by fastidious mico-organisms. Sodium chloride maintains the osmotic and ionic equilibrium and disodium phosphate provides the basic buffering capacity.Параметрыform buffered powder Quality Level 200, quality Microbiologically tested.
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Tryptose Phosphate Broth solution
NACRES: NA.75
Кат. номер T8159-PH T8159-100ML ApplicationIn addition to its use for the growth of fastidious micro-organisms, Tryptose Phospate Broth (TPB) has been studied as supplement for the preparation of media that supports vaccine production in BHK-21 cells and the growth of SF21 insect cells in high-density perfusion culture stirred-tank bioreactors.ComponentsTryptose Phosphate Broth (TPB) is composed of four components: Tryptose (20g/L); Dextrose (2g/L); NaCl (5g/L) and Disodium Phosphate (2.5g/L) typically adjusted to pH 7.3. The tryptose component is a peptone (mixture of amino acids and short peptides) derived by the mixed enzymatic hydrolysis (pancreatic enzymes) of the milk protein casein. This hydrolysate provides a source of amino acid based nutrients and survival factors that support the growth of fastidious micro-organisms such as Brucella, Streptococcus, and Neisseria; as well as eukaryotic cells such as insect and animal cells. Dextrose provides a fermentable carbohydrate that can be used by fastidious mico-organisms. Sodium chloride maintains the osmotic and ionic equilibrium and disodium phosphate provides the basic buffering capacity.ПараметрыQuality Level 300 sterility sterile-filtered form solution concentration 29.5 g/L in deionized water application(s) cell culture | mammalian: suitable shipped in ambient storage temp. room temp
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 2 Flash Point(F) Not applicable Flash Point(C) Not applicable Узнать цену -
Yeast Brewers
CAS Number: 68876-77-7 NACRES: NA.75
Кат. номер Y4625-1KG Y4625-5KG Y4625-250G ПараметрыQuality Level 200, product line BioReagent form powder application(s) cell culture | insect: suitable solubility 0.1 M sodium bicarbonate: 200 mg/mL, turbid shipped in ambient storage temp. 2-8°C InChI 1S/C19H14O2/c20-18(21)11-17-15-8-4-3-7-14(15)16-10-9-12-5-1-2-6-13(12)19(16)17/h1-10,17H,11H2,(H,20,21) InChI key GQNBDGXKDJSVGQ-UHFFFAOYSA-N
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()-Bilobalide from Ginkgo biloba leaves
Empirical Formula (Hill Notation): C15H18O8 CAS Number: 33570-04-6 Molecular Weight: 326.30 MDL number: MFCD00238547 PubChem Substance ID: 24892116
Кат. номер B9031-10MG B9031-25MG B9031-100MG General descriptionBilobalide is a biologically active terpenic trilactone (terpenoid) extracted from Ginkgo biloba. It is synthesized from geranylgeranyl pyrophosphate (GGPP).Application(-)-Bilobalide from Ginkgo biloba leaves has been used as a reference substance to study the antimicrobial activity of different fractions of G.biloba leaves against a number of Gram-positive and negative bacteria and yeasts.Packaging25, 100 mg in poly bottle
10 mg in glass insertBiochem/physiol ActionsBilobalide is an inducer of cytochrome P450 enzymes CYP3A1 and CYP1A2. It exhibits neuroprotective, anti-inflammatory, anti-oxidative and anti-apoptotic properties. Bilobalide, a -aminobutyric acid (GABA) AA-rho, 5-hydroxytryptamine type 3 (5-HT(3)) receptor antagonist, may be used to study the function of these receptors in the brain processes such as cognition and memory. It serves as a specific platelet-activating factor receptor antagonist, which helps in the treatment of cardiovascular (Alzheimers disease) and cerebrovascular diseases.
Bioactive terpenoid found in Ginkgo biloba.Параметрыbiological source plant leaves (Ginkgo biloba) Quality Level 100, assay 93% (HPLC) form powder application(s) HPLC: suitable color white storage temp. 20°C SMILES string CC(C)(C)[C@]1(O)CC2OC(=O)C[C@@]23C(=O)OC4OC(=O)[C@H](O)[C@]134 InChI 1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13-,14+,15+/m0/s1 InChI key MOLPUWBMSBJXER-YDGSQGCISA-N
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()-Riboflavin
Empirical Formula (Hill Notation): C17H20N4O6 CAS Number: 83-88-5 Molecular Weight: 376.36 Beilstein/REAXYS Number: 97825 EC Number: 201-507-1 MDL number: MFCD00005022 eCl@ss: 34058005 PubChem Substance ID: 57654591 NACRES: NA.79
Кат. номер R4500-500G R4500-100G R4500-1KG R4500-25G R4500-5G R4500-5G-KC R4500-BR General descriptionRiboflavin belongs to the vitamin-B family and contains a pentose side chain ribitol.ApplicationRiboflavin has been used:- to check the role of riboflavin diet in rats
- as a supplement in HECM-6 medium (hamster embryo culture medium)
- as a supplement in the bacterial basal media
Packaging1 kg in poly drum
5, 25, 100 g in glass bottle
500 g in poly drumBiochem/physiol ActionsRiboflavin is a key component of the redox cofactors flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) that are used by a wide variety of flavoprotein oxidoreductases, dehydrogenase(s), decarboxylase(s) and electron transporters. Riboflavin is involved in various cellular processes, including β oxidation in lipid metabolism, glucose metabolism, protection from cellular oxidative injury, DNA and RNA metabolism, gluconeogenesis, erythropoiesis and generation of corticosteroids. Riboflavin deficiency causes ariboflavinosis with symptoms such as sore throat, hyperemia, edema of oral and mucous membranes, cheilosis and glossitis.Параметрыbiological source Eremothecium ashbyii Quality Level 200, assay ≥98% form powder color yellow to orange mp 290 °C (dec.) (lit.) storage temp. room temp SMILES string CC1=C(C)C=C(N(C[C@H](O)[C@@H]([C@H](O)CO)O)C(C2=N3)=NC(NC2=O)=O)C3=C1 InChI 1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1 InChI key AUNGANRZJHBGPY-SCRDCRAPSA-N
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(+)--Tocopherol
Empirical Formula (Hill Notation): C28H48O2 CAS Number: 54-28-4 Molecular Weight: 416.68 Beilstein/REAXYS Number: 93072 EC Number: 200-201-5 MDL number: MFCD00066529 eCl@ss: 34058016 PubChem Substance ID: 24899992 NACRES: NA.79
Кат. номер T1782-100MG T1782-5MG T1782-25MG Application(+)--Tocopherol has been used:- as reference material for the quantification of -tocopherol in the oil sample using high performance liquid chromatography with diode array detector (HPLC/DAD)(192}
- as a component of diet to feed vitamin-E-depleted rats to study its effects
- as an additive in the feed to study its effects in reducing dietary induced oxidative stress in vivo and improving meat lipid stability in broilers
Packaging5, 25, 100 mg in glass bottleBiochem/physiol ActionsTocopherols (TCP) (vitamin E) are a series (, , and ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble antioxidants that protect cell membranes from oxidative damage. -Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.ПараметрыQuality Level 200 assay ≥96% (HPLC) form liquid application(s) HPLC: suitable color dark brown, colorless to dark yellow storage temp. 2-8°C SMILES string CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2cc(O)c(C)c(C)c2O1 InChI 1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h19-22,29H,8-18H2,1-7H3/t21-,22-,28-/m1/s1 InChI key QUEDXNHFTDJVIY-DQCZWYHMSA-N Gene Information human ... HMGCR(3156)
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(+)--Tocopherol acetate
Empirical Formula (Hill Notation): C31H52O3 CAS Number: 58-95-7 Molecular Weight: 472.74 EC Number: 200-405-4 MDL number: MFCD00072052 eCl@ss: 34058007 PubChem Substance ID: 24899940 NACRES: NA.75
Кат. номер T1157-10G T1157-1G General descriptionα-Tocopherol acetate is a semisynthetic acetate ester of naturally occurring α-tocopherol.ApplicationUse in insect cell culture applications as an antioxidant.
(+)--Tocopherol acetate has been used:- as a supplement in the human embryonic kidney cells (HEK 293) to assess its impact on cell growth
- as a component of Dulbeccos Modified Eagle Medium/Nutrient Mixture F-12 (DMEM/F12) for immortalized chondrocyte cell line
- as a component of serum-free medium for human colon tissue organ culture
- to test its antioxidant effects on cow articular chondrocytes
Packaging1, 10 g in glass bottleBiochem/physiol Actionsα-Tocopherol acetate or vitamin E-acetate has antioxidant properties and reduces lipid peroxidation. However, vitamin E acetate on pyrolysis leads to the generation of carcinogens like alkenes and benzenes.CautionSince the M.P. is about 25 °C this preparation is usually an oil. Does not air oxidize.ПараметрыQuality Level 200, biological source plant description Synthesized from natural -tocopherol product line BioReagent form liquid (or semi-solid) specific activity ~1360 IU/g mol wt Mw 472.74 g/mol purified by crystallization application(s) cell culture | insect: suitable color white to yellow solubility chloroform: soluble 50 mg/mL, clear, colorless to yellow storage temp. room temp SMILES string CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1 InChI 1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1 InChI key ZAKOWWREFLAJOT-CEFNRUSXSA-N
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(+)-Biotin N-hydroxysuccinimide ester
Empirical Formula (Hill Notation): C14H19N3O5S CAS Number: 35013-72-0 Molecular Weight: 341.38 Beilstein/REAXYS Number: 4720781 MDL number: MFCD00078531 PubChem Substance ID: 24895479 NACRES: NA.46
Кат. номер H1759-1G H1759-100MG H1759-PM H1759-25MG H1759-5MG H1759-250MG ApplicationMay be used in the biotinylation of proteins and peptides. Typically coupled to primary amine in the pH range 6.5-8.5.DisclaimerUnless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.ПараметрыQuality Level 200, assay ≥98% (HPLC) form powder reaction suitability reaction type: Biotinylations color white to off-white mp 212 °C solubility DMF: ≤50 mg/mL (Stable for at least one month in dry DMF), DMSO: soluble storage temp. −20°C SMILES string [H][C@]12CS[C@@H](CCCCC(=O)ON3C(=O)CCC3=O)[C@@]1([H])NC(=O)N2 InChI 1S/C14H19N3O5S/c18-10-5-6-11(19)17(10)22-12(20)4-2-1-3-9-13-8(7-23-9)15-14(21)16-13/h8-9,13H,1-7H2,(H2,15,16,21)/t8-,9-,13-/m0/s1 InChI key YMXHPSHLTSZXKH-RVBZMBCESA-N
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(+)-Magnesium L-ascorbate
Empirical Formula (Hill Notation): C12H14MgO12 CAS Number: 15431-40-0 Molecular Weight: 374.54 Beilstein/REAXYS Number: 3767527 EC Number: 239-442-6 MDL number: MFCD00137683 PubChem Substance ID: 57653604 NACRES: NA.79
Кат. номер 94417-100G-F 94417-500G-F General description(+)-Magnesium L-ascorbate or vitamin C magnesium salt is a water-soluble molecule. It is naturally present in a variety of foods such as citrus fruits and vegetables.Biochem/physiol ActionsL-Ascorbic acid (Vitamin C) exhibits anti-oxidant properties in both plants and animals. In plants, it facilitates various cellular processes such as growth, programmed cell death, pathogen responses, hormone responses, flowering and senescence, as well as protection against environmental stresses. Ascorbic acid acts as a reducing agent in various enzymatic reactions to reduce oxidative stress. L-Ascorbate has an ability to inhibit bacterial mutagenesis induced by N-nitroso compounds. Vitamin C deficiency leads to scurvy, prominent-gingivitis, perifollicular hemorrhages, poor wound healing, petechiae and ecchymosis.ПараметрыQuality Level 100, assay 90% (T) form powder color white to faintly beige SMILES string OC[C@@H](O)[C@@H]1OC(=O)C(O)=C1O[Mg]OC2=C(O)C(=O)O[C@H]2[C@H](O)CO InChI 1S/2C6H8O6.Mg/c2*7-1-2(8)5-3(9)4(10)6(11)12-5;/h2*2,5,7-10H,1H2;/q;;+2/p-2/t2*2-,5+;/m11./s1 InChI key AIOKQVJVNPDJKA-GVKKNTFRSA-L
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(+)-Sodium L-ascorbate
Empirical Formula (Hill Notation): C6H7NaO6 CAS Number: 134-03-2 Molecular Weight: 198.11 Beilstein/REAXYS Number: 3767246 EC Number: 205-126-1 MDL number: MFCD00082340 eCl@ss: 34058010 PubChem Substance ID: 24891261 NACRES: NA.79
Кат. номер A7631-100G A7631-500G A7631-25G A7631-1KG General descriptionAscorbic acid, also known as vitamin C, is a water-soluble vitamin. L-Ascorbic acid is a reducing agent.Application(+)-Sodium L-ascorbate has been used:- as a component of cutting solution for storing brain slices of rats
- as a component of patch pipette internal solution for imaging Ca2+ transients evoked by action potential in rat brain slices
- as a supplement for arterial smooth muscle cell (SMC) cultures to encourage collagen production
Packaging25, 100, 500 g in poly bottle
1 kg in poly bottleBiochem/physiol ActionsAscorbic acid exhibits anti-oxidant properties. It is a primary substrate for detoxifying hydrogen peroxide. Ascorbic acid is a co-factor for the synthesis of adrenal steroids and catecholamines. L-Ascorbic acid (Vitamin C) is a water soluble molecule used in a wide variety of applications, including cell culture, as a reducing agent that helps reduce oxidative stress. L-Ascorbate can be regenerated by biological systems.CautionMay darken in storage.ПараметрыQuality Level 300 biological source synthetic assay 98% form crystalline application(s) HPLC: suitable color white to off-white mp 220 °C (dec.) (lit.) SMILES string [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] InChI 1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1 InChI key PPASLZSBLFJQEF-RXSVEWSESA-M
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(24R)-24,25-Dihydroxyvitamin D3
Empirical Formula (Hill Notation): C27H44O3 CAS Number: 55721-11-4 Molecular Weight: 416.64 Beilstein/REAXYS Number: 4567039 MDL number: MFCD00941417 PubChem Substance ID: 57647691 NACRES: NA.79
Кат. номер 17943-1MG 17943-100UG General description(24R)-24,25-Dihydroxyvitamin D3 or secalciferol is produced in kidney. It is the one of the most active form of vitamin D and an essential circulating vitamin D3 metabolite.Application(24R)-24,25-Dihydroxyvitamin D3 has been used to assess its function(s) compared with that of 1,25(OH)2D3, during osteoblastic differentiation of primary human mesenchymal stem cells (hMSCs).Packaging100 μg in poly bottle
1 mg in poly bottle
Bottomless glass bottle. Contents are inside inserted fused cone.Biochem/physiol Actions(24R)-24,25-Dihydroxyvitamin D3 plays an essential role in calcium and phosphorus homeostasis. (24R)-24,25-Dihydroxyvitamin D3 along with 1,25(OH)2D3 stimulates bone metabolism.
Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 24R,25-Dihydroxyvitamin D3 is a catabolite of 25-Dihydroxyvitamin D3 and a putative regulator of developmental bone formation. 24R,25-Dihydroxyvitamin D3 is a substrate for renal 25-hydroxyvitamin D3 1 -hydroxylase. 24R,25-Dihydroxyvitamin D3 is an endogenous regulator of apo A-I synthesis through a VDR-independent signaling mechanism and an inhibitor of Pi-induced apoptosis through Ca2+, PLD, and PLC signaling and through LPA-LPA1/3-G(i)-PI(3)K-mdm2-mediated p53 degradation.ПараметрыQuality Level 200, biological source synthetic assay 98% (vitamin + pre-vitamin, HPLC) form powder or crystals color colorless to white storage temp. 20°C SMILES string [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CC[C@@H](O)C(C)(C)O InChI 1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25-,27-/m1/s1 InChI key FCKJYANJHNLEEP-XRWYNYHCSA-N
Safety Informationpictograms GHS06,GHS08 signalword Danger hcodes H301 + H311 - H330 - H372 pcodes P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P310 - P314 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges, RIDADR UN 2811 6.1 / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(R)-Pantetheine
Empirical Formula (Hill Notation): C11H22N2O4S CAS Number: 496-65-1 Molecular Weight: 278.37 Beilstein/REAXYS Number: 1714196 MDL number: MFCD00056757 PubChem Substance ID: 329751343 NACRES: NA.79
Кат. номер 16702-500MG 16702-50MG 16702-10MG Biochem/physiol ActionsMetabolite in carbapenem biosynthesis, pantothenate and CoA biosynthesis and biosynthesis of secondary metabolites.ПараметрыQuality Level 100, assay 95.0% (HPLC) form solid optical activity []/D 17±2°, c = 1 in H2O color white storage temp. 20°C SMILES string OCC(C)(C)[C@@H](O)C(NCCC(NCCS)=O)=O InChI 1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 InChI key ZNXZGRMVNNHPCA-VIFPVBQESA-N
Safety InformationRIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
(±)--Tocopherol
Empirical Formula (Hill Notation): C29H50O2 CAS Number: 10191-41-0 Molecular Weight: 430.71 Beilstein/REAXYS Number: 94012 EC Number: 233-466-0 MDL number: MFCD00006848 eCl@ss: 34058016 PubChem Substance ID: 24900118 NACRES: NA.77
Кат. номер T3251-100G T3251-5G T3251-500G T3251-25G Application(±)-α-Tocopherol has been used for preparing mycobacterial emulsions. It has also been used to study its immunomodulatory effect on influenza virus.Packaging5, 25, 100, 500 g in glass bottleBiochem/physiol ActionsTocopherols (vitamin E) comprise of a series (α, β, γ and δ) of chiral compounds that differ by the methylation degree of the phenol moiety of the chromanol ring. They function as lipid soluble antioxidants and protect cell membranes from oxidative damage. α-tocopherols are favorably absorbed by humans and their nicotinate salts can function as vitamin E supplements. Studies have also reported that vitamin E can prevent cell damage caused by pharmacologically induced epilepsy in rats.Preparation Note(±)-α-Tocopherol is miscible with chloroform, ethanol, ether, acetone, and vegetable oils. However, it is practically insoluble in water. (±)-α-Tocopherol is unstable under alkaline conditions.ПараметрыQuality Level 200 biological source synthetic assay 96% (HPLC) form liquid application(s) HPLC: suitable color faint brown to brown, yellow to very dark yellow solubility H2O: insoluble, acetone: miscible, chloroform: miscible, ethanol: miscible, vegetable oils: miscible density 0.950 g/mL at 20 °C (lit.) storage temp. 2-8°C SMILES string CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1 InChI 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3 InChI key GVJHHUAWPYXKBD-UHFFFAOYSA-N
Safety InformationPictograms GHS07 Signal Word Warning Hazard Statements H317 Precautionary Statements P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364 Personal Protective Equipment Eyeshields, Gloves RIDADR NONH for all modes of transport WGK Germany WGK 1 Узнать цену -
(±)--Tocopherol nicotinate
Empirical Formula (Hill Notation): C35H53NO3 CAS Number: 51898-34-1 Molecular Weight: 535.80 EC Number: 257-501-4 MDL number: MFCD03548047 PubChem Substance ID: 24900260 NACRES: NA.79
Кат. номер T5134-5G T5134-25G T5134-100G General descriptionα-Tocopherol nicotinate is a fat soluble vitamin. It is an ester of tocopherol and niacin. Niacin is linked to the hydroxyl group of active vitamin E in this ester. α-Tocopherol is a form of vitamin E, which is available through dietary sources. RRR-α-tocopherol is a natural form of α-Tocopherol.Application(±)-α-Tocopherol nicotinate has been used in metabolic studies to assess its biological functions in rats.Packaging5, 25, 100 g in glass bottleBiochem/physiol ActionsTocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. α-Tocopherol nicotinate is used along the α-Tocopherol acetate, α-Tocopherol succinate and other esterified forms as a vitamin E supplement with similar but differential activities.
α-Tocopherol is a radical-chain breaker owing to its anti-oxidant property.Параметрыassay ≥98% Quality Level 100, form solid or liquid color white to yellow storage temp. 2-8°C SMILES string CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)c3cccnc3)c(C)c(C)c2O1 InChI 1S/C35H53NO3/c1-24(2)13-9-14-25(3)15-10-16-26(4)17-11-20-35(8)21-19-31-29(7)32(27(5)28(6)33(31)39-35)38-34(37)30-18-12-22-36-23-30/h12,18,22-26H,9-11,13-17,19-21H2,1-8H3/t25-,26-,35-/m1/s1 InChI key MSCCTZZBYHQMQJ-AZAGJHQNSA-N
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(±)--Tocopherol phosphate disodium salt
Empirical Formula (Hill Notation): C29H49Na2O5P Linear Formula: C29H49O5PNa2 CAS Number: 60934-46-5 Molecular Weight: 554.65 MDL number: MFCD00079579 eCl@ss: 34058016 PubChem Substance ID: 24900007 NACRES: NA.79
Кат. номер 2550044 T2020-1G T2020-250MG T2020-BR Application(±)-α-Tocopherol phosphate disodium salt has been used as an antioxidant, to assess its protection against oxidative damage in rat hippocampal neurons. It has also been used to study its molecular mechanisms and transport across the plasma membrane.Packaging250 mg in poly bottle
1 g in poly bottleBiochem/physiol ActionsTocopherols (TCP) (vitamin E) are a series (, , and ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. -Tocopherol is the form of tocopherol preferentially absorbed by Homo sapiens. -Tocopherol phosphate (TocP) is used along the -tocopherol acetate, -tocopherol-nicotinate, -tocopherol succinate and other esterified forms as a vitamin E supplement with similar but differential activities.Параметрыbiological source synthetic (organic) Quality Level 200, assay ≥97% (HPLC) form powder application(s) HPLC: suitable color white to off-white storage temp. 2-8°C SMILES string [Na].CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(OP(O)(O)=O)c(C)c(C)c2O1 InChI 1S/C29H51O5P.Na.H/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(34-35(30,31)32)23(5)24(6)28(26)33-29;;/h20-22H,9-19H2,1-8H3,(H2,30,31,32);; InChI key QRLCTLIPEFQSSG-UHFFFAOYSA-N
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(±)-Catechin hydrate
Empirical Formula (Hill Notation): C15H14O6 · xH2O CAS Number: 7295-85-4 Molecular Weight: 290.27 (anhydrous basis) Beilstein/REAXYS Number: 92762 EC Number: 230-731-2 MDL number: MFCD00149354 PubChem Substance ID: 57653989 NACRES: NA.79
Кат. номер C1788-500MG C1788-1G C1788-5G General descriptionCatechin is produced by Cutch tree and is abundantly found in tea leaves, grape seeds, vegetables and plant-based beverages. It is a plant-derived, polyphenolic anti-oxidant and acts as a plant secondary metabolite.Application(±)-Catechin hydrate has been used:- to study its modulatory effect on drug resistance in human ovarian cancer cells
- to construct the standard curve of total flavonoid content
- to study its effects on the physiological parameters of Solanum lycopersicum
Packaging1 g in glass bottleBiochem/physiol ActionsCatechin has phytotoxic properties. Racemic catechin may be used in studies on seed germination and plant invasiveness. Catechin and Epigallocatechin gallate (EGCG) may be used with other polyphenol flavonoids to study their effects in oxidation and peroxidation-related processes.
Polyphenolic antioxidant. Used in traditional Chinese medicine.Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C1788.pdf, Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,Параметрыassay ≥96% (HPLC) Quality Level 200, form powder application(s) HPLC: suitable color white to light brown mp 200 °C (decomposes on heating) storage temp. 2-8°C SMILES string [H]O[H].O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 InChI 1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-5,13,15-20H,6H2;1H2/t13-,15+;/m0./s1 InChI key OFUMQWOJBVNKLR-NQQJLSKUSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H315 - H319 - H335 pcodes P302 + P352 - P305 + P351 + P338 Target Organs Respiratory system Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
-Carotene
Empirical Formula (Hill Notation): C40H56 CAS Number: 7235-40-7 Molecular Weight: 536.87 Beilstein/REAXYS Number: 1917416 EC Number: 230-636-6 MDL number: MFCD00001556 PubChem Substance ID: 24893189 NACRES: NA.79
Кат. номер C9750-5G C9750-25G C9750-10G C9750-1G General descriptionCarotenoids are an important class of naturally occurring pigments found in fruits and vegetables. Among the carotenoids, β-carotene has the greatest provitamin A potential and functions to reduce the risk of cancer, cardiovascular diseases and macular degeneration. Low water solubility and poor chemical stability attributes to low absorption of β-carotene from food. β-carotene along with digestible lipids enriches its bio accessibility. Emulsions or nano emulsions encapsulates effectively delivers lipophilic β-carotene and increases its bioavailability. β-carotene has anti-oxidant potential and reduces noise induced hearing loss and progression of macular degeneration.Application-carotene has been used:- to generate nano emulsions to evaluate their bioavailability potential
- as a standard, for -carotene evaluation in blood and skin samples using high performance liquid chromatography (HPLC),
- as a dietary supplement of vitamin-A in young rats by HPLC
- as a dietary supplement in mice to reduce hearing loss and hair cell damage
Packaging5, 10, 25 g in glass bottle
Packaged in serum vials.Biochem/physiol ActionsThe most important of the provitamins A, -carotene can be classified as an antioxidant due to its inhibition of radical initiated peroxidation in vitro. However, in vivo it appears to act either as an antioxidant or a prooxidant depending on cellular environment. It reduces the incidence of many cancers, but enhances lung cancer incidence in smokers.CautionPurchase minimum quantity required. Discard one month after opening.Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C9750.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,ПараметрыQuality Level 200, biological source synthetic assay ≥93% (UV) form powder potency ~1,600,000 units vitamin A per g color dark red to brown mp 178-179 °C solubility hexane: 1.1 mg/mL, DMSO: 30 μg/mL storage temp. 2-8°C SMILES string CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)(C)CCC1 InChI 1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+ InChI key OENHQHLEOONYIE-JLTXGRSLSA-N
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-Cryptoxanthin
Empirical Formula (Hill Notation): C40H56O CAS Number: 472-70-8 Molecular Weight: 552.87 PubChem Substance ID: 329775121 NACRES: NA.79
Кат. номер C6368-1MG C6368-1MG-PW General descriptionβ-Cryptoxanthin is an oxygen-containing carotenoid and is a member of the xanthophyll family. It is one of the major sources of vitamin A and is present in fruits such as oranges, tangerines and papayas. In addition, it is also found in corn, peas and some animal products such as egg yolk and butter.Application-Cryptoxanthin has also been used to study its effect on the production of immunoglobulins in Peyers patch cells ex- vivo. It has also been used as a standard in high-performance liquid chromatography (HPLC analysis).(5)Biochem/physiol Actions-Cryptoxanthin exhibits potential-anabolic effect on bone calcification by stimulating osteoblastic bone formation and inhibiting osteoclastic bone resorption in vitro. It acts as an antioxidant and avoids free radical damage to biomolecules such as lipids, proteins and nucleic acids. High dietary intake of -cryptoxanthin reduces the risk of developing rheumatoid arthritis and lung cancer.
Carotenoid pigment with antioxidant functionality. In vivo conversion of -cryptoxanthin to retinol can occur in humans. Inhibits carcinogenic induced urinary bladder cancer in experimental animal models.Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C6368.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,ПараметрыQuality Level 100, assay ≥97% (TLC) form powder color faint red to very dark red mp 169-170 °C solubility chloroform: 1 mg/mL storage temp. −20°C SMILES string CC(=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C1=C(C)C[C@@H](O)CC1(C)C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C InChI 1S/C40H56O/c1-30(18-13-20-32(3)23-25-37-34(5)22-15-27-39(37,7)8)16-11-12-17-31(2)19-14-21-33(4)24-26-38-35(6)28-36(41)29-40(38,9)10/h11-14,16-21,23-26,36,41H,15,22,27-29H2,1-10H3/b12-11+,18-13+,19-14+,25-23+,26-24+,30-16+,31-17+,32-20+,33-21+/t36-/m1/s1 InChI key DMASLKHVQRHNES-FKKUPVFPSA-N
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-Nicotinamide adenine dinucleotide hydrate
Empirical Formula (Hill Notation): C21H27N7O14P2 · xH2O CAS Number: 53-84-9 Molecular Weight: 663.43 (anhydrous basis) EC Number: 200-184-4 MDL number: MFCD00036253 eCl@ss: 39200202 PubChem Substance ID: 24897495 NACRES: NA.55
Кат. номер N1511-1G-C 2540047 N1511-1G N1511-5G N1511-VAR N1511-250MG N1511-500MG N1511-100MG Application-Nicotinamide adenine dinucleotide hydrate has been used:- to prepare NAD+ standard solution for a study on NAD+ metabolomics
- as a component of MurI assay reaction partial mixture for glutamate racemase reaction
- as a component of a chromogenic staining solution to stain zebrafish embryos
Packaging250 mg in poly bottle
1, 5 g in poly bottle
Packaged by solid weight.Biochem/physiol Actions-Nicotinamide adenine dinucleotide (-NAD) is a cofactor of alcohol dehydrogenase and acts as an inhibitory neurotransmitter in visceral smooth muscles. The NAD/NADH ratio has a role in the regulation of intracellular redox potential. It thereby influences metabolic reactions in vivo.
Electron acceptorOther NotesCrystalline NAD contains less than 0.1% (w/w) residual organic solvent, is less hygroscopic and electrostatic, and is more stable at ambient temperature than amorphous NAD.
This is the common form of NAD.Параметрыbiological source Saccharomyces cerevisiae Quality Level 200, assay 99% form crystalline powder color white to off-white storage temp. 20°C SMILES string NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O InChI 1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 InChI key BAWFJGJZGIEFAR-NNYOXOHSSA-N Gene Information human ... ESR1(2099), ESR2(2100)
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-Tocopherol
Empirical Formula (Hill Notation): C29H50O2 CAS Number: 10191-41-0 Molecular Weight: 430.71 Beilstein/REAXYS Number: 94012 EC Number: 233-466-0 MDL number: MFCD00006848 eCl@ss: 34058016 PubChem Substance ID: 57648149
Кат. номер 258024-500G 258024-100G 258024-5G General descriptionα-Tocopherol is the active form of vitamin E. It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses. α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease. It has antiproliferative effects. It inhibits arsenite-induced damage of human fibroblasts.Application-Tocopherol has been used:- as a standard to determine its concentration by reverse-phase high-performance liquid chromatography
- to study its rescue effects on chlorine dioxide (ClO2) cytotoxicity
- to assess its protective effects on acetaminophen (APAP)-mediated liver damage
Packaging5, 100, 500 g in glass bottleBiochem/physiol ActionsTocopherols (TCP) (vitamin E) are a series (, , and ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. -Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.ПараметрыQuality Level 200, biological source synthetic assay ≥95.5% form liquid application(s) HPLC: suitable, cell analysis: suitable color faint brown to brown, yellow to very dark yellow density 0.950 g/mL at 20 °C (lit.) storage temp. 2-8°C SMILES string CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1 InChI 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3 InChI key GVJHHUAWPYXKBD-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H317 pcodes P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364 Personal Protective Equipment Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 1 Узнать цену -
1,25-Dihydroxyvitamin D2 17944-1MG-F
Empirical Formula (Hill Notation): C28H44O3 CAS Number: 60133-18-8 Molecular Weight: 428.65 Beilstein/REAXYS Number: 5635017 MDL number: MFCD00869499 PubChem Substance ID: 57647692 NACRES: NA.79 Packaging1 mg in poly bottle
Bottomless glass bottle. Contents are inside inserted fused cone.Biochem/physiol ActionsErgocalciferol (vitamin D2) is activated in vivo by hydroxylation to 25-hydroxyergocalciferol and 1,25-dihydroxycalciferol. Activated Vitamin D2 molecules may be used in a wide range of studies to assess their effects on functions such as immune function and calcium homeostasis.Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 17944.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,ПараметрыQuality Level 200, biological source synthetic assay 97.0% (sum of vitamin and previtamin, HPLC) form crystals color white to light yellow storage temp. 70°C SMILES string C[C@H](\C=C\[C@H](C)C(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C InChI 1S/C28H44O3/c1-18(9-10-19(2)27(4,5)31)24-13-14-25-21(8-7-15-28(24,25)6)11-12-22-16-23(29)17-26(30)20(22)3/h9-12,18-19,23-26,29-31H,3,7-8,13-17H2,1-2,4-6H3/b10-9+,21-11+,22-12-/t18-,19+,23-,24-,25+,26+,28-/m1/s1 InChI key ZGLHBRQAEXKACO-XJRQOBMKSA-N
Safety Informationpictograms GHS06,GHS08 signalword Danger hcodes H301 + H311 - H330 - H372 pcodes P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P310 - P314 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges, RIDADR UN 2811 6.1 / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
1,25-Dihydroxyvitamin D3
Empirical Formula (Hill Notation): C27H44O3 CAS Number: 32222-06-3 Molecular Weight: 416.64 Beilstein/REAXYS Number: 7559394 EC Number: 250-963-8 MDL number: MFCD00867079 eCl@ss: 34058003 PubChem Substance ID: 24893473 NACRES: NA.79
Кат. номер D1530-.1MG-PW D1530-10UG D1530-.1MG D1530-10UG-PW Biochem/physiol ActionsBiologically active form of vitamin D3 in calcium absorption and deposition. 1,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.
Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.ПараметрыQuality Level 300 assay 99% (HPLC) application(s) HPLC: suitable storage temp. 20°C SMILES string [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O InChI 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1 InChI key GMRQFYUYWCNGIN-NKMMMXOESA-N Gene Information human ... VDR(7421)
Safety InformationPictograms GHS06,GHS08 Signal Word Danger Hazard Statements H300 + H310 + H330 - H372 Precautionary Statements P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314 Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges RIDADR UN 2811 6.1 / PGI WGK Germany WGK 2 Flash Point(F) Not applicable Flash Point(C) Not applicable Узнать цену -
1-Hydroxyvitamin D3 17946-1MG
Empirical Formula (Hill Notation): C27H44O2 CAS Number: 41294-56-8 Molecular Weight: 400.64 EC Number: 255-297-1 MDL number: MFCD00868328 PubChem Substance ID: 57647693 NACRES: NA.79 General description1-Hydroxyvitamin D3, also known as alfacalcidol, is a synthetic vitamin D3 analogue, hydroxylated in position one. It is metabolized to 1,25-dihydroxycholecalciferol by 25-hydroxylases.Biochem/physiol Actions1-Hydroxyvitamin D3 facilitates calcium absorption and deposition. It also has an ability to inhibit bone resorption and stimulate bone formation. Alfacalcidol is used for treating various bone diseases such as rickets/osteomalacia, renal osteodystrophy and osteoporosis. It acts as a chemopreventive agent and reduces the risk colitis and carcinogenesis.
Synthetic vitamin D3 analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.PackagingBottomless glass bottle. Contents are inside inserted fused cone.ПараметрыQuality Level 100, biological source synthetic assay 97.0% (HPLC) form powder or crystals color white to off-white storage temp. 20°C SMILES string CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C InChI 1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1 InChI key OFHCOWSQAMBJIW-AVJTYSNKSA-N Gene Information human ... VDR(7421)
Safety Informationpictograms GHS06 signalword Danger hcodes H300 pcodes P301 + P330 + P331 + P310 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges, RIDADR UN 2811 6.1 / PGI WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
13-cis-Retinoic acid
Empirical Formula (Hill Notation): C20H28O2 CAS Number: 4759-48-2 Molecular Weight: 300.44 EC Number: 225-296-0 MDL number: MFCD00079542 PubChem Substance ID: 24278676
Кат. номер R3255-100MG R3255-500MG R3255-250MG Application13-cis-Retinoic acid has been used:- as a component of fresh media for LA-N-5 differentiation
- to treat medulloblastoma cells for cell differentiation
- to treat spheroids for generating time-lapse videos
- to examine its head- deforming activity under light and dark conditions in Xenopus laevis
Packaging100, 250, 500 mg in ampuleBiochem/physiol Actions13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action. The action of RA is mediated through RAR- and RAR- receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.Features and BenefitsThis compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here, to learn more.Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R3255.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,Legal InformationLOPAC is a registered trademark of Sigma-Aldrich Co. LLCПараметрыQuality Level 200, assay 98% (HPLC) form powder application(s) HPLC: suitable color yellow to yellow-orange mp 172-175 °C (lit.) storage temp. 20°C SMILES string [H]\C(C(O)=O)=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C InChI 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- InChI key SHGAZHPCJJPHSC-XFYACQKRSA-N Gene Information human ... NOS2(4843), RARA(5914), RARB(5915), RARG(5916)
Safety Informationpictograms GHS07,GHS08 signalword Danger hcodes H315 - H319 - H335 - H360 pcodes P201 - P302 + P352 - P305 + P351 + P338 - P308 + P313 Target Organs Respiratory system Personal Protective Equipment Eyeshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
2-O-a-D-Glucopyranosyl-L-ascorbic Acid
Empirical Formula (Hill Notation): C12H18O11 CAS Number: 129499-78-1 Molecular Weight: 338.26 MDL number: MFCD23701380 PubChem Substance ID: 329824985 NACRES: NA.79
Кат. номер SMB00390-1G SMB00390-1000MG General description2-O-a-D-glucopyranosyl-L-ascorbic acid, generally known as ascorbyl glucoside, is a relatively novel compound and is a stable vitamin C derivative. Over a long period of time, it gradually is converted into ascorbic acid.
2-O-a-D-Glucopyranosyl-L-ascorbic Acid is derived from L-ascorbic acid and -glucosyl donor saccharide, in the presence of -isomaltosylglucosaccharide producing enzyme.
2-O-a-D-Glucopyranosyl-L-ascorbic acid is a form of vitamin C combined with glucose.Application2-O-a-D-Glucopyranosyl-L-ascorbic acid has been used to develop an in vitro 3D model of the stromal-nerve interactions of the human cornea.Packaging1 g in poly bottleBiochem/physiol Actions2-O-a-D-glucopyranosyl-L-ascorbic acid or ascorbyl glucoside functions as a skin whitener and radical scavenger in cosmetics. It is responsible for the bleaching action of bleaching cosmetics. This compound is activated in a manner identical to that of vitamin C. The enzyme present in the epidermal basal membrane, ascorbyl phosphatase, slowly converts 2-O-a-D-glucopyranosyl-L-ascorbic acid into vitamin C, thereby maintaining a high vitamin C level in skin throughout the day.
2-O-a-D-Glucopyranosyl-L-ascorbic acid can function as an antioxidant, an antineoplastic, and a tyrosine kinase inhibitor.ПараметрыQuality Level 200, assay 98% (HPLC) form powder application(s) HPLC: suitable, tissue processing: suitable color white to off-white mp 158-163 °C storage temp. 2-8°C SMILES string OC([C@]([C@@H](O)CO)([H])O1)=C(C1=O)O[C@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO InChI 1S/C12H18O11/c13-1-3(15)9-8(19)10(11(20)22-9)23-12-7(18)6(17)5(16)4(2-14)21-12/h3-7,9,12-19H,1-2H2/t3-,4+,5+,6-,7+,9+,12+/m0/s1 InChI key MLSJBGYKDYSOAE-DCWMUDTNSA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
2-Phospho-L-ascorbic acid trisodium salt
Empirical Formula (Hill Notation): C6H6Na3O9P · xH2O CAS Number: 66170-10-3 Molecular Weight: 322.05 (anhydrous basis) MDL number: MFCD03095479 NACRES: NA.79
Кат. номер 49752-100G 49752-10G 49752-1KG Application2-Phospho-L-ascorbic acid trisodium salt has been used as medium supplement in Dulbeccos Modified Eagle Medium (DMEM) for adipose-derived stem cells, human mesenchymal stem cells and osteoblast cells.Biochem/physiol ActionsL-Ascorbic acid 2-phosphate (AA2P) is used in biocatalytic dephosphorylation for electric power generation and electrochemical detection assays. L-Ascorbic acid 2-phosphate may be used in cell differentiation and tissue engineering applications. Asc-2P is used in studies of gene repression, such as the repression of dihydrotestosterone-induced dickkopf-1 expression.ПараметрыQuality Level 200, biological source synthetic assay 95.0% (HPLC) form powder application(s) cell culture | mammalian: suitable impurities 7.5% water (Karl Fischer) color white to off-white pH 9.0-9.5 (25 °C, 30 g/L in H2O) mp 260 °C anion traces chloride (Cl-): 50 mg/kg, sulfate (SO42-): 50 mg/kg cation traces Al: 10 mg/kg, As: 2 mg/kg, Ba: 5 mg/kg, Cd: 5 mg/kg, Co: 5 mg/kg, Cr: 5 mg/kg, Cu: 5 mg/kg, Fe: 10 mg/kg, Mg: 10 mg/kg, Mn: 5 mg/kg, Mo: 5 mg/kg, Ni: 5 mg/kg, Pb: 5 mg/kg, Sr: 5 mg/kg, Zn: 5 mg/kg
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
22,23-Dihydroergocalciferol 88815-1MG
Empirical Formula (Hill Notation): C28H46O CAS Number: 511-28-4 Molecular Weight: 398.66 EC Number: 208-127-5 MDL number: MFCD18781880 PubChem Substance ID: 329769672 NACRES: NA.79 General description22,23-Dihydroergocalciferol, also known as vitamin D4, is derived from fungi such as yeast. It is synthesized from the precursor ergosta-5,7-dienol (22,23-dihydroergosterol).PackagingBottomless glass bottle. Contents are inside inserted fused cone.ПараметрыQuality Level 100, assay 97.0% (HPLC) form powder color white storage temp. 20°C SMILES string CC(C)[C@@H](C)CC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C InChI 1S/C28H46O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h12-13,19-20,22,25-27,29H,4,7-11,14-18H2,1-3,5-6H3/b23-12+,24-13-/t20-,22+,25-,26+,27-,28+/m0/s1 InChI key DIPPFEXMRDPFBK-JPWDPSJFSA-N
Safety Informationpictograms GHS06,GHS08 signalword Danger hcodes H301 + H311 - H330 - H372 pcodes P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P310 - P314 RIDADR UN 2811 6.1 / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
25-Hydroxycholecalciferol H4014-1MG
Empirical Formula (Hill Notation): C27H44O2 CAS Number: 19356-17-3 Molecular Weight: 400.64 EC Number: 242-990-9 MDL number: MFCD00867077 PubChem Substance ID: 24895612 NACRES: NA.79 Packaging1 mg in glass bottleBiochem/physiol ActionsErgocalciferol (vitamin D2) and 25-Hydroxycholecalciferol (vitamin D3) are the two form of vitamin D which are activated in vivo by hydroxylation. Vitamin D2 and D3 may be used in a wide range of studies to assess their effects on function such as immune function and calcium homeostasis.ПараметрыQuality Level 200, assay ≥98% (HPLC) form powder application(s) HPLC: suitable color white to off-white storage temp. −20°C SMILES string C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C InChI 1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 InChI key JWUBBDSIWDLEOM-DTOXIADCSA-N Gene Information human ... VDR(7421)
Safety Informationpictograms GHS06,GHS08 signalword Danger hcodes H301 + H311 - H330 - H372 pcodes P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P310 - P314 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges, RIDADR UN 2811 6.1 / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
25-Hydroxyvitamin D2 17937-1MG
Empirical Formula (Hill Notation): C28H44O2 CAS Number: 21343-40-8 Molecular Weight: 412.65 Beilstein/REAXYS Number: 4716773 MDL number: MFCD02683431 eCl@ss: 34058017 PubChem Substance ID: 57647689 Packaging1 mg in poly bottle
Amber polypropylene vialBiochem/physiol ActionsErgocalciferol (vitamin D2) is activated in vivo by hydroxylation to 25-hydroxyergocalciferol and 1,25-dihydroxycalciferol. Activated Vitamin D2 molecules may be used in a wide range of studies to assess their effects on functions such as immune function and calcium homeostasis.Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 17937.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,ПараметрыQuality Level 200, biological source synthetic assay 95.0% (HPLC) form crystals color white to colorless mp 88.0-95.0 °C storage temp. 70°C SMILES string [H][C@@]12CC[C@H]([C@H](C)\C=C\[C@H](C)C(C)(C)O)[C@@]1(C)CCC/C2=C\C=C3\C[C@@H](O)CCC3=C InChI 1S/C28H44O2/c1-19-10-14-24(29)18-23(19)13-12-22-8-7-17-28(6)25(15-16-26(22)28)20(2)9-11-21(3)27(4,5)30/h9,11-13,20-21,24-26,29-30H,1,7-8,10,14-18H2,2-6H3/b11-9+,22-12+,23-13-/t20-,21+,24+,25-,26+,28-/m1/s1 InChI key KJKIIUAXZGLUND-ICCVIKJNSA-N
Safety Informationpictograms GHS06,GHS08 signalword Danger hcodes H301 + H311 - H330 - H372 pcodes P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P310 - P314 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges, RIDADR UN 2811 6.1 / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
25-Hydroxyvitamin D3 monohydrate 17938-1MG
Empirical Formula (Hill Notation): C27H44O2 · H2O CAS Number: 63283-36-3 Molecular Weight: 418.65 Beilstein/REAXYS Number: 4270041 MDL number: MFCD00867077 eCl@ss: 34058003 PubChem Substance ID: 57647690 NACRES: NA.79 Biochem/physiol ActionsCholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 25-dihydroxycholecalciferol is a the major circulating form of vitamin D3 and a physiological precursor of 1α,25-Dihydroxycholecalciferol. The conversion is catalyzed by 25-Hydroxyvitamin D3 1-α-hydroxylase (VD3 1A hydroxylase) also known ascytochrome p450 27B1 (CYP27B1).PackagingBottomless glass bottle. Contents are inside inserted fused cone.ПараметрыQuality Level 200, biological source synthetic assay 99.0% (HPLC) form powder or crystals color white to off-white shipped in dry ice storage temp. 20°C SMILES string [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CCCC(C)(C)O InChI 1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 InChI key JWUBBDSIWDLEOM-DTOXIADCSA-N Gene Information human ... VDR(7421)
Safety Informationpictograms GHS06,GHS08 signalword Danger hcodes H300 + H310 + H330 - H372 pcodes P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310 - P314 Personal Protective Equipment Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges, RIDADR UN 2811 6.1 / PGII WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
![4-(N-[2,4-Diamino-6-pteridinylmethyl]amino)benzoic acid sodium salt](/data/small/ps_393080_0.png)
4-(N-[2,4-Diamino-6-pteridinylmethyl]amino)benzoic acid sodium salt
Empirical Formula (Hill Notation): C14H12N7NaO2 Linear Formula: C14H12N7O2Na CAS Number: 100929-45-1 Molecular Weight: 333.28 MDL number: MFCD00006709 PubChem Substance ID: 24893425
Кат. номер D1393-50MG D1393-250MG D1393-100MG Application4-(N-[2,4-Diamino-6-pteridinylmethyl]amino)benzoic acid is an impurity found in methotrexate preparations. It may be used as a reference compound in methothrexate purity analysis.Packaging50 mg in poly bottleПараметрыbiological source synthetic (organic) Quality Level 200, assay ≥95% (TLC) form powder color yellow to orange SMILES string [Na+].Nc1nc(N)c2nc(CNc3ccc(cc3)C([O-])=O)cnc2n1 InChI 1S/C14H13N7O2.Na/c15-11-10-12(21-14(16)20-11)18-6-9(19-10)5-17-8-3-1-7(2-4-8)13(22)23;/h1-4,6,17H,5H2,(H,22,23)(H4,15,16,18,20,21);/q;+1/p-1 InChI key NDXULQWYAMJQGC-UHFFFAOYSA-M
Safety Informationpictograms GHS07 signalword Warning hcodes H302 + H312 + H332 pcodes P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
6-O-Palmitoyl-L-ascorbic acid
Empirical Formula (Hill Notation): C22H38O7 CAS Number: 137-66-6 Molecular Weight: 414.53 Beilstein/REAXYS Number: 96552 EC Number: 205-305-4 MDL number: MFCD00005377 PubChem Substance ID: 57652625 NACRES: NA.79
Кат. номер 76183-25G 76183-100G General description6-O-Palmitoyl-L-ascorbic acid is a lipid soluble ester of ascorbic acid. Ascorbic acid 6-palmitate is a lipophilic derivative of ascorbic acid.Application6-O-Palmitoyl-L-ascorbic acid has been used to study the effects of dietary supplement in Solea senegalensis larvae.Packaging25, 100 g in poly bottleBiochem/physiol Actions6-O-Palmitoyl-L-ascorbic acid possesses metastasis inhibitory and anti-tumor activity. Ascorbyl palmitate exhibits antioxidant activity by protecting the cell membranes from oxidative damage.ПараметрыQuality Level 200, biological source synthetic product line BioXtra assay 99.0% (RT) form powder optical activity []20/D +23±1°, c = 1% in ethanol ign. residue 0.2% (as SO4) loss 0.2% loss on drying color white to faint yellow mp 113-116 °C cation traces Ca: 50 mg/kg, Cd: 5 mg/kg, Co: 5 mg/kg, Cr: 5 mg/kg, Cu: 5 mg/kg, Fe: 5 mg/kg, K: 50 mg/kg, Mg: 5 mg/kg, Mn: 5 mg/kg, Na: 100 mg/kg, Ni: 5 mg/kg, Pb: 5 mg/kg, Zn: 5 mg/kg SMILES string CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O InChI 1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21+/m0/s1 InChI key QAQJMLQRFWZOBN-LAUBAEHRSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H319 pcodes P264 - P280 - P305 + P351 + P338 - P337 + P313 Personal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
7-Dehydrocholesterol
Empirical Formula (Hill Notation): C27H44O CAS Number: 434-16-2 Molecular Weight: 384.64 Beilstein/REAXYS Number: 2224615 EC Number: 207-100-5 MDL number: MFCD00003624 eCl@ss: 39023139 PubChem Substance ID: 57648485 NACRES: NA.79
Кат. номер 30800-5G-F 30800-1G-F 30800-25G-F General description7-Dehydrocholesterol (7-DHC), a 5,7-conjugated diene sterol is a biosynthetic precursor of cholesterol. It helps in the production of vitamin D3 when exposed to ultraviolet B (UVB) radiation.Application7-Dehydrocholesterol has been used as an internal standard to determine sterols.Biochem/physiol ActionsDown-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 30800.pdf, Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,ПараметрыQuality Level 100, biological source synthetic assay ≥95.0% (HPLC) form powder or crystals optical activity [α]20/D -115±8°, c = 1% in chloroform color white to faint yellow mp 148-152 °C (lit.) storage temp. −20°C SMILES string [H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C InChI 1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 InChI key UCTLRSWJYQTBFZ-DDPQNLDTSA-N
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
9-cis-Retinal
Empirical Formula (Hill Notation): C20H28O CAS Number: 514-85-2 Molecular Weight: 284.44 EC Number: 208-188-8 MDL number: MFCD00135842 PubChem Substance ID: 24899382
Кат. номер R5754-100MG R5754-PH R5754-25MG Application9-cis-Retinal has been used for visual pigment regeneration.Packaging25, 100 mg in ampuleBiochem/physiol ActionsRetinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
9-cis retinal is a natural ligand (chromophore) of the vertebrate rod visual pigment. 9-cis retinal is used in studies on the mechanisms of visual function.Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R5754.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,ПараметрыQuality Level 200, assay 95% (HPLC) form powder application(s) HPLC: suitable color yellow to yellow-orange mp 56-58 °C (lit.) shipped in dry ice storage temp. 20°C SMILES string CC(=C\C=O)/C=C/C=C(C)\C=C\C1=C(C)CCCC1(C)C InChI 1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8-,17-13+ InChI key NCYCYZXNIZJOKI-MKOSUFFBSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 + H312 + H332 - H315 pcodes P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
9-cis-Retinoic acid R4643-1MG
Empirical Formula (Hill Notation): C20H28O2 CAS Number: 5300-03-8 Molecular Weight: 300.44 MDL number: MFCD00270072 PubChem Substance ID: 24899373 NACRES: NA.77 Application9-cis-Retinoic acid has been used:- as ligand for retinoid X receptor gamma (RXR) for inducing oligodendrocyte precursor cells differentiation and remyelination
- as a medium component to study its effect on UDP-glucuronosyltransferases (UGT) expression in thyroid induced hepatocytes
- to induce lymphangiogenesis in lymphatic endothelial cell
Packaging1 mg in ampule
Sealed ampuleBiochem/physiol ActionsLigand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells.
9-cis-Retinoic acid (9cRA) is an isomer of all-trans-retinoic acid (ATRA), both of which are lipid molecules synthesized from a common precursor, vitamin A. 9cRA is a potent agonist for retinoid X receptor (RXR) and retinoic acid receptor (RAR). It has neurotrophic functionality, promotes neuronal differentiation and may have therapeutic potential in treating stroke. It also regulates cytokine secretion and lymphocyte proliferation. 9cRA favors the dopamine cells survival and induces neuroprotection in neurodegenerative disorder like parkinsons disease. It elicits anti-inflammatory function and stimulates mast cells and inhibits interleukin 4 and 5 expression levels. 9cRA is in clinical trial phase II for treating refractory cancer.Features and BenefitsThis compound is featured on the Nuclear Receptors (Non-Steroids), page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here,.
This compound is a featured product for Gene Regulation research. Click here, to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm,.Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R4643.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,Параметрыbiological source natural Quality Level 200, assay 98% (HPLC) form powder application(s) HPLC: suitable color light yellow to yellow-orange mp 189-190 °C storage temp. 20°C SMILES string CC1=C(\C=C\C(C)=C/C=C/C(C)=C/C(O)=O)C(C)(C)CCC1 InChI 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+ InChI key SHGAZHPCJJPHSC-ZVCIMWCZSA-N Gene Information human ... RARA(5914), RARB(5915), RARG(5916), RXRA(6256), RXRB(6257), RXRG(6258)
Safety Informationpictograms GHS07,GHS08 signalword Danger hcodes H315 - H319 - H335 - H360 pcodes P201 - P302 + P352 - P305 + P351 + P338 - P308 + P313 Target Organs Respiratory system Personal Protective Equipment Eyeshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Acipimox
Empirical Formula (Hill Notation): C6H6N2O3 CAS Number: 51037-30-0 Molecular Weight: 154.12 EC Number: 256-928-3 NACRES: NA.79
Кат. номер A7856-1G A7856-5G Packaging1 g in poly bottleBiochem/physiol ActionsAcipimox, also known as olbemox, is a nicotinic acid analog. It functions as an anti-lipolytic drug and vasodilator. Acipimox may be used in various metabolic studies involving insulin and ghrelin. It lowers total cholesterol and total triglycerides, which helps in the treatment of hyperlipidemia.
Niacin-derived, vasodilator studied for its lipid-lowering effect.ПараметрыQuality Level 100, assay ≥99% (TLC) form powder color off-white to faint yellow mp 177-180 °C storage temp. 2-8°C InChI 1S/C6H6N2O3/c1-4-2-7-3-5(6(9)10)8(4)11/h2-3H,1H3,(H,9,10) InChI key DNRXJHATQULEHC-UHFFFAOYSA-N
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Adenine
Empirical Formula (Hill Notation): C5H5N5 CAS Number: 73-24-5 Molecular Weight: 135.13 Beilstein/REAXYS Number: 5777 EC Number: 200-796-1 MDL number: MFCD00041790 PubChem Substance ID: 24891349 NACRES: NA.51
Кат. номер A8626-5G A8626-100G A8626-1G A8626-25G A8626-1KG General descriptionAdenine is a purine nucleobase. It is part of DNA, and RNA. Adenine is also a component of cofactors (NAD, FAD) and signaling molecules (cAMP).ApplicationAdenine is suitable for use:- as a component of boron-deficient media to grow yeast in order to assess whether yeast growth is stimulated by boron
- as a food supplement for adult rats to investigate the effects of dietary adenine overload
- as a nucleic acid base supplement in the basal media used to grow anaerobic Bacillus mojavensis and Bacillus subtilis in a study to show that DNA or deoxyribonucleosides are required for the anaerobic growth of these bacteria
- as an additive to investigate the effects of adenine on CH4 production and on fermentation by ruminal batch cultures from nonlactating Holstein cows
- as a part of adenine diet in rats in a study to identify blood markers for early stages of adenine-induced chronic kidney disease (CKD)
Packaging1, 5, 25, 100 g in poly bottle
1 kg in poly bottleBiochem/physiol ActionsAdenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to is 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease (CKD) with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds.ПараметрыQuality Level 200, biological source synthetic assay 99% form powder application(s) UV/Vis spectroscopy: suitable color white to off-white mp >360 °C (lit.) solubility 0.5 M HCl: soluble 20 mg/mL, Grade III, colorless to faint yellow or tan storage temp. room temp SMILES string Nc1ncnc2[nH]cnc12 InChI 1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) InChI key GFFGJBXGBJISGV-UHFFFAOYSA-N Gene Information human ... AKT1(207), GSK3B(2932), LCK(3932), MAP3K1(4214), MAPK14(1432), MAPK8(5599), MAPK9(5601), MAPKAPK2(9261), PRKACA(5566), PRKCA(5578), RAF1(5894), ROCK2(9475)
mouse ... Mapk1(26413)
rat ... Camk2a(25400), Mapk10(25272)
Safety Informationpictograms GHS06 signalword Danger hcodes H301 pcodes P264 - P270 - P301 + P310 - P405 - P501 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Faceshields,, Gloves, RIDADR UN 2811 6.1 / PGIII WGK Germany WGK 3 Узнать цену -
all trans-Retinal
Empirical Formula (Hill Notation): C20H28O CAS Number: 116-31-4 Molecular Weight: 284.44 MDL number: MFCD00001550 PubChem Substance ID: 24899355 NACRES: NA.79
Кат. номер R2500-100MG R2500-1G R2500-100MG-PW R2500-PH R2500-25MG R2500-500MG R2500-500MG-PW General descriptionAll trans-Retinal is one of the major derivatives of vitamin A group. A variety of food serves as a source of vitamin A. It is predominant in liver and among the brightly colored vegetables.ApplicationAll trans-Retinal has been used:- in optogenetic experiments
- in electrophysiological experiment
- to study the effect of AKR1B10 (aldo-keto reductase (AKR) superfamily member) on the conversion of retinal to retinol in the airway epithelium
- in decidual transformation of human endometrial stromal cells
Packaging25, 100, 500 mg in ampule
1 g in ampule
Sealed ampule.Biochem/physiol ActionsAll-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells. Retinal isomers are also chromophores that bind to opsins, a family of G-protein-linked transmembrane proteins, to form photosensitive receptors in visual and nonvisual systems. All-trans retinal is a potent photosensitizer.Other NotesTandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R2500.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,Параметрыbiological source synthetic (organic) Quality Level 200, assay ≥98% form powder application(s) HPLC: suitable color yellow mp 62-64 °C shipped in dry ice storage temp. −20°C SMILES string [H]C(=O)\C=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C InChI 1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ InChI key NCYCYZXNIZJOKI-OVSJKPMPSA-N
Safety InformationPersonal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 3 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Aloe-emodin
Empirical Formula (Hill Notation): C15H10O5 CAS Number: 481-72-1 Molecular Weight: 270.24 Beilstein/REAXYS Number: 2059062 EC Number: 207-571-7 MDL number: MFCD00017373 PubChem Substance ID: 24891267 NACRES: NA.79
Кат. номер A7687-25MG A7687-100MG General descriptionAloe-emodin is a hydroxyanthraquinone found naturally in aloe plants.ApplicationAloe-emodin has been used as a standard in high performance liquid chromatography (HPLC) for separation and identification of phenolic compounds in Aloe arborescens Miller var. natalensis Berger (Kidachi aloe).Packaging25 mg in glass bottleBiochem/physiol ActionsAloe-emodin exhibits antibacterial, antiviral, anti-inflammatory and hepatoprotective effects.
Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.ПараметрыQuality Level 200, biological source plant root (Rheum palmatum) assay ≥95% (HPLC) form powder application(s) HPLC: suitable color yellow to brown storage temp. 2-8°C SMILES string OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1 InChI 1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2 InChI key YDQWDHRMZQUTBA-UHFFFAOYSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H302 pcodes P301 + P312 + P330 Personal Protective Equipment dust mask type N95 (US),, Eyeshields,, Gloves, RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Ascorbic acid 6-palmitate
Empirical Formula (Hill Notation): C22H38O7 CAS Number: 137-66-6 Molecular Weight: 414.53 Beilstein/REAXYS Number: 96552 EC Number: 205-305-4 MDL number: MFCD00005377 PubChem Substance ID: 24890608 NACRES: NA.21
Кат. номер A1968-1KG A1968-100G A1968-25G A1968-VAR General descriptionAscorbic acid 6-palmitate/L-Ascorbyl 6-palmitate (AP) is a derivative of a synthetic lipophilic ascorbic acid.Packaging1 kg in poly drum
25, 100 g in poly bottleBiochem/physiol ActionsL-Ascorbyl 6-palmitate (AP) is used as preservative in foods. In mice, AP works as a dietary antitumor promoter.ПараметрыQuality Level 200, biological source synthetic Agency/Method USP/NF, meets USP testing specifications assay 95.0-100.5% form powder color light yellow Featured Industry Pharmaceutical (small molecule) SMILES string CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O InChI 1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21+/m0/s1 InChI key QAQJMLQRFWZOBN-LAUBAEHRSA-N
Safety Informationpictograms GHS07 signalword Warning hcodes H319 pcodes P264 - P280 - P305 + P351 + P338 - P337 + P313 Personal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Biotin
Empirical Formula (Hill Notation): C10H16N2O3S CAS Number: 58-85-5 Molecular Weight: 244.31 Beilstein/REAXYS Number: 86838 EC Number: 200-399-3 MDL number: MFCD00005541 eCl@ss: 34058011 PubChem Substance ID: 24891778 NACRES: NA.21
Кат. номер B4501-10MG-KC B4501-100MG B4501-VAR B4501-100MG-KC B4501-5G B4501-10G B4501-1G B4501-25G B4501-500MG B4501-BR ApplicationBiotin may be used to elute proteins from avidin/streptavidin resins.- It has been used for culturing of oligodendrocytes.
- It has been used as a vitamin supplement for the growth of Bacillus species.
- It has been used for blocking endogenous biotin during immunohistology procedures.
Packaging100, 500 mg in poly bottle
1, 5, 10, 25 g in poly bottleBiochem/physiol ActionsBiotin is a small molecule and its presence with biologically active macromolecules does not affect the biological function of the macromolecule. The biotin-(strept)avidin system are required for various applications. Biotin also works as a cofactor of carboxylating enzymes, such as pyruvate carboxylase. It catalyzes the formation of oxaloacetate from pyruvate and CO2. Biotin conjugation with avidin or streptavidin helps in linking the target molecule (antibody, nucleotide, protein A etc.) with the labeling system (enzyme, fluorescent, chemiluminescent probes). This complex is used for many detection systems, such as immunoassays, DNA hybridization assays, immunohistochemistry and flow-cytometry. This approach is also applied for the purification and characterization of various molecules of interest.ПараметрыQuality Level 300 biological source synthetic (organic) assay ≥99% (HPLC) form lyophilized powder application(s) HPLC: suitable color white to off-white mp 231-233 °C (lit.) solubility ammonium hydroxide: 50 mg/mL (2 M) storage temp. 2-8°C SMILES string [H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2 InChI 1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1 InChI key YBJHBAHKTGYVGT-ZKWXMUAHSA-N
Safety InformationPersonal Protective Equipment Eyeshields, Gloves, type N95 (US) RIDADR NONH for all modes of transport WGK Germany WGK 1 Flash Point(F) Not applicable Flash Point(C) Not applicable Узнать цену -
Biotin, immobilized on Dextran
NACRES: NA.25
Кат. номер 14402-VAR 14402-25MG 14402-10MG General descriptionBiotin/vitamin B7/vitamin H is a water-soluble B complex vitamin. It consists of an uredo ring fused by a tetrahydrothiophene ring. Biotin is readily available in several foods, like whole grains, nuts, legumes, unpolished rice and egg yolk. The normal gut flora also produces this vitamin.ApplicationDextrans are used in many applications as volume extenders, stabilizers, matrix components, binding platforms, lubricants and physical structure components. Biotinylated dextran may be used to capture or detect avidin/strepavidin conjugated molecules.
Biotin, immobilized on dextran has been used in in vivo labeling of the lectin structures of vascular endothelium to demonstrate the functionality of CD31+ vessels.Biochem/physiol ActionsBiotin acts as an important cofactor for carboxylase enzymes in various metabolic pathways. It is implicated in keratin synthesis and hence is used as a supplement for skin, hair and nail growth. Biotin functions as a coenzyme in the metabolism of fats, fatty acids and amino acids such as isoleucine and valine. It is involved in gluconeogenesis and citric acid cycle. Biotin is essential for cell growth.It assists the transfer of carbon dioxide and also maintains a steady blood sugar level.ПараметрыQuality Level 100, biological source synthetic assay 99.0% (TLC) form powder mol wt Mr ~70000 extent of labeling 5-25 mol/mol substitution (biotin) application(s) detection: suitable color colorless to white solubility H2O: 50 mg/mL, slightly hazy, faintly yellow storage temp. 2-8°C
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, type N95 (US), RIDADR NONH for all modes of transport WGK Germany WGK 2 Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
BME Vitamins 100x solution
MDL number: MFCD00282655 NACRES: NA.75
Кат. номер B6891-1L B6891-100ML B6891-500ML ApplicationBME Vitamins 100x solution is used in MOPS modified medium (MMM). It has been used as a supplement in several growth media.Параметрыsterility sterile-filtered Quality Level 200, product line BioReagent form liquid application(s) cell culture | mammalian: suitable color yellow to dark yellow shipped in dry ice storage temp. −20°C
Safety InformationPersonal Protective Equipment Eyeshields,, Gloves,, multi-purpose combination respirator cartridge (US), RIDADR NONH for all modes of transport WGK Germany nwg Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Cafestol acetate
Empirical Formula (Hill Notation): C22H30O4 CAS Number: 81760-48-7 Molecular Weight: 358.47 MDL number: MFCD00133152 PubChem Substance ID: 24892399 NACRES: NA.79
Кат. номер C1305-100MG C1305-25MG ApplicationCafestol acetate has been used to determine the effects of coffee on heat shock response (HSR).Packaging100 mg in poly bottleBiochem/physiol ActionsCafestol is a coffee-specific diterpene. It has anti-carcinogenic and anti-inflammatory activities. Cafestol stimulates apoptosis in cells associated with colorectal and renal cancer (Caki cells). It is used to study mechanisms of anti-oxidation related to hydrogen peroxide induced oxidative stress and DNA damage. Cafestol increases the level of glutathione (GSH), by stimulating γ-glutamylcysteine synthetase. It acts as a chemopreventive agent by inducing cytochrome P-450.Other NotesFuran-containing diterpene from green coffee beans.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C1305.pdf , Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.,ПараметрыQuality Level 100, assay ≥98% form powder application(s) HPLC: suitable color white to off-white storage temp. 2-8°C SMILES string CC(=O)OCC1(O)CC23CCC4c5ccoc5CCC4(C)C2CCC1C3 InChI 1S/C22H30O4/c1-14(23)26-13-22(24)12-21-9-5-17-16-7-10-25-18(16)6-8-20(17,2)19(21)4-3-15(22)11-21/h7,10,15,17,19,24H,3-6,8-9,11-13H2,1-2H3 InChI key PTGGVIKFNQSFBY-UHFFFAOYSA-N
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Canthaxanthin 11775-1MG
Empirical Formula (Hill Notation): C40H52O2 CAS Number: 514-78-3 Molecular Weight: 564.84 Beilstein/REAXYS Number: 1898520 EC Number: 208-187-2 MDL number: MFCD00016364 PubChem Substance ID: 329749552 NACRES: NA.32 General descriptionCanthaxanthin (red diketocarotenoid or 4, 4′-diketo-β-carotene), is a common xanthophyll found naturally in microorganisms and marine organisms, as well as in certain animals. It acts as an antioxidant in living organisms. The potential antioxidant activity of canthaxanthin is due to the presence of conjugated double bonds in its structure. It finds applications in various fields including poultry, fishery, cosmetics, medicine, and pharmaceuticals. In food industries, canthaxanthin can be used as a coloring agent.ПараметрыQuality Level 100, biological source synthetic assay 95.0% (HPLC) form powder or crystals color light red to dark brown in hexane (with 2% dichloromethane) UV absorption : 465 nm±5 nm Amax storage temp. 20°C SMILES string CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)CCC1(C)C)\C=C\C=C(C)\C=C\C2=C(C)C(=O)CCC2(C)C InChI 1S/C40H52O2/c1-29(17-13-19-31(3)21-23-35-33(5)37(41)25-27-39(35,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-36-34(6)38(42)26-28-40(36,9)10/h11-24H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+ InChI key FDSDTBUPSURDBL-DKLMTRRASA-N
Safety InformationRIDADR NONH for all modes of transport WGK Germany nwg Flash Point F Not applicable Flash Point C Not applicable Узнать цену -
Cholecalciferol
Empirical Formula (Hill Notation): C27H44O CAS Number: 67-97-0 Molecular Weight: 384.64 Beilstein/REAXYS Number: 2339331 EC Number: 200-673-2 MDL number: MFCD00078131 eCl@ss: 34058003 PubChem Substance ID: 24893192 NACRES: NA.26
Кат. номер C9756-1G C9756-5G C9756-250MG General descriptionCholecalciferol acts as a hormone precursor since it requires two stages of metabolism: first to 25-hydroxycholecalciferol; then to 1α, 25-dihydroxycholecalciferol. One unit (U.S.P. or international) is defined as the activity of 0.025 μg of vitamin D3 contained in the USP vitamin D reference standard.
Cholecalciferol is sourced either through the diet or exposing skin to ultraviolet rays. Oral administration of vitamin D3 is readily absorbed and is stored in adipose tissue.Packaging1, 5 g in glass bottleBiochem/physiol ActionsDeficiency of vitamin D is often observed in chronic kidney disease.
Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.Storage and StabilityCholecalciferol C9756 is packaged under argon gas. If it is stored unopened at 2-8°C and protected from light, this product should be stable for a minimum of three years. Unused portions should be stored under nitrogen or argon gas. Deterioration is negligible after storage of one year in amber-evaculated ampules at refrigerator temperatures. It is oxidized and inactivated by moist air within a few days.ПараметрыQuality Level 200 biological source synthetic (organic) assay ≥98% (HPLC) form powder application(s) HPLC: suitable color white to off-white mp 83-86 °C (lit.) storage temp. 2-8°C SMILES string CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C InChI 1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1 InChI key QYSXJUFSXHHAJI-YRZJJWOYSA-N Gene Information human ... VDR(7421)
Safety InformationPictograms GHS06,GHS08 Signal Word Danger Hazard Statements H300 + H310 + H330 - H372 Precautionary Statements P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314 Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges RIDADR UN 2811 6.1 / PGII WGK Germany WGK 2 Flash Point(F) Not applicable Flash Point(C) Not applicable Узнать цену
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