Cycloheximide

Empirical Formula (Hill Notation):	C15H23NO4
CAS Number:	66-81-9
Molecular Weight:	281.35
Beilstein/REAXYS Number:	88868
EC Number:	200-636-0
MDL number:	MFCD00082346
PubChem Substance ID:	329747360
NACRES:	NA.85

Кат. номер

1810-5G

1810-1G

1810-25G

Cyclohexamide (CHX) is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins, super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques, activate cumulus-free equine oocytes, and to have neuroprotective properties.
Cycloheximide (CHX) is an antibiotic produced by Strptomyces sp.. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.
Cyclohexamide inhibits protein biosynthesis in eukaryotic cells by binding with the 80S ribosome.
1G, 5G
Conditions for safe storage, including any incompatibilities. Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Quality Level	200,
biological source	microbial
assay	≥95% (HPLC)
form	powder or crystals
color	white to light beige
mp	110-120 °C
Mode of action	protein synthesis | interferes
antibiotic activity spectrum	fungi, yeast
InChI	1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key	YPHMISFOHDHNIV-FSZOTQKASA-N
Gene Information	human ... FKBP1A(2280), PIN1(5300)

pictograms	GHS06,GHS08,GHS09
signalword	Danger
hcodes	H300 - H341 - H360D - H411
pcodes	P201 - P273 - P301 + P310 + P330
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	UN2811 - class 6.1 - PG 2 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable