Actinomycin D

Empirical Formula (Hill Notation):	C62H86N12O16
CAS Number:	50-76-0
Molecular Weight:	1255.42
Beilstein/REAXYS Number:	605235
EC Number:	200-063-6
MDL number:	MFCD00005033
PubChem Substance ID:	24890541
NACRES:	NA.85

Кат. номер

A1410-100MG-PW

A1410-10MG-PW

A1410-25MG-PW

A1410-2MG-PW

A1410-5MG-PW

A1410-100MG

A1410-10MG

A1410-25MG

A1410-2MG

A1410-5MG

A1410-50MG

Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity.
Chemical structure: peptide
Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm′s tumour and the sarcomas.
2, 5, 10, 25, 100 mg in serum bottle
Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.
This product is hygroscopic and light-sensitive. If stored protected from light and moisture at 2-8°C, it remains unchanged, by HPLC testing, for at least 15 months. Unused dilute solutions of Actinomycin D are extremely sensitive to light and tend to adsorb to plastic and glass and should be discarded. However, frozen aliquots of concentrated stock solution are stable for at least a month.
Actinomycin D is sold as red, shiny crystals and is soluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL. Some references also show slight solubility in water of 0.5 mg/mL.
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

biological source	Streptomyces sp.
Quality Level	300,
assay	~98% (HPLC)
form	powder
optical activity	[]/D alpha: 28/D (Rotation: -315 degrees (c=0.25% in methanol))
color	red to orange, red, powder
mp	251-253
solubility	DMSO: 1 mg/mL, ethanol: soluble
Mode of action	DNA synthesis | interferes
antibiotic activity spectrum	neoplastics
storage temp.	2-8°C
SMILES string	CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3OC4=C(C)C(=O)C(N)=C(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)C4=Nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]7CCCN7C1=O
InChI	1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
InChI key	RJURFGZVJUQBHK-IIXSONLDSA-N

pictograms	GHS06,GHS08
signalword	Danger
hcodes	H300 - H350 - H360FD
pcodes	P201 - P202 - P264 - P270 - P280 - P301 + P310
Personal Protective Equipment	Eyeshields,, Faceshields,, Gloves,, type P1 (EN143) respirator filter,, type P3 (EN 143) respirator cartridges,
RIDADR	UN 3462 6.1 / PGII
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable