Sulindac
| Empirical Formula (Hill Notation): | C20H17FO3S |
| CAS Number: | 38194-50-2 |
| Molecular Weight: | 356.41 |
| EC Number: | 253-819-2 |
| MDL number: | MFCD00599589 |
| PubChem Substance ID: | 57654635 |
| NACRES: | NA.77 |
| Кат. номер |
| S8139-5G |
| S8139-25G |
Treatment of human colorectal cancer cell lines induces MRP1 and MRP3 but not other members of the MRP family. Reported to significantly increase the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine. Sulindac was tested for its effect on heat-induced denaturation of albumin
in vitro28 and its ability to bind to human plasma protein.29
5, 25 g in poly bottle
Sulindac is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells25,26 and reduces tumor burden in adenomatous polyposis patients.27
Nonsteroidal anti-inflammatory; preferential inhibitor of COX-1.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
| Quality Level | 200 |
| biological source | synthetic (organic) |
| assay | 98.0% |
| form | powder |
| application(s) | HPLC: suitable, gas chromatography (GC): suitable |
| solubility | methanol: 50 mg/mL |
| Featured Industry | Forensics and Toxicology Veterinary |
| originator | Merck & Co., Inc., Kenilworth, NJ, U.S. |
| SMILES string | CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(C)=O |
| InChI | 1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- |
| InChI key | MLKXDPUZXIRXEP-MFOYZWKCSA-N |
| Gene Information | human ... ALB(213), PTGS1(5742), PTGS2(5743) |
| pictograms | GHS06,GHS08 |
| signalword | Danger |
| hcodes | H301 - H317 - H334 - H361 |
| pcodes | P201 - P280 - P301 + P310 + P330 - P302 + P352 |
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point F | Not applicable |
| Flash Point C | Not applicable |