Empirical Formula (Hill Notation): | C26H29Cl2N5O3 |
CAS Number: | 380843-75-4 |
Molecular Weight: | 530.45 |
MDL number: | MFCD07367846 |
PubChem Substance ID: | 329823766 |
NACRES: | NA.77 |
Bosutinib is a safe oral medicine with good bioavailability. It is effective for treating chronic myeloid leukemia (CML). It is also a potent ATP-competitive inhibitor for Src tyrosine kinase. Bosutinib inhibits epidermal growth factor receptor (EGFR). It suppresses solid tumors associated with breast, pancreas and prostate.
Packaging
5 mg in glass bottle
Biochem/physiol Actions
Bosutinib (SKI-606) is an orally active; dual Src/Abl tyrosine kinase inhibitor with potent antiproliferative activity. It does not appear to inhibit c-Kit and PDGRF, which are thought to be the cause of numerous side effects in anticancer treatment with some other tyrosine kinase inhibitors.
Features and Benefits
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Quality Level | 100, |
assay | 98% (HPLC) |
form | powder |
Торговая марка | Pfizer® |
color | off-white to light brown |
solubility | DMSO: 15 mg/mL |
originator | Pfizer |
storage temp. | room temp |
SMILES string | COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl |
InChI | 1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) |
InChI key | UBPYILGKFZZVDX-UHFFFAOYSA-N |
Gene Information | human ... ABL1(25), HCK(3055), LYN(4067), SRC(6714) |
pictograms | GHS07 |
signalword | Warning |
hcodes | H319 - H413 |
pcodes | P273 - P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point F | Not applicable |
Flash Point C | Not applicable |