Cholecalciferol (Vitamin D3)

Empirical Formula (Hill Notation):	C27H44O
CAS Number:	67-97-0
Molecular Weight:	384.64
Beilstein/REAXYS Number:	2339331
EC Number:	200-673-2
MDL number:	MFCD00078131
PubChem Substance ID:	329823242
NACRES:	NA.24

Кат. номер

PHR1237-500MG

PHR1237-500MG-PW

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cholecalciferol (vitamin D3) is a fat-soluble vitamin that manifests skeletal and extra-skeletal effects. The skeletal effects augment the bone health whereas the extra-skeletal effects concern the immune system, the cognition, the cardiovascular system, etc.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Cholecalciferol (Vitamin D3) may be used as a pharmaceutical reference standard for the determination of the analyte in food, feeds, serum samples and pharmaceutical formulations by various chromatography techniques.
Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0270 in the slot below. This is an example certificate only and may not be the lot that you receive.

Quality Level	300
grade	certified reference material, pharmaceutical secondary standard
form	neat, solid
CofA	current certificate can be downloaded
application(s)	HPLC: suitable, gas chromatography (GC): suitable
mp	83-86 °C (lit.)
Featured Industry	Cleaning Products Cosmetics Food and Beverages Personal Care Pharmaceutical (small molecule)
format	neat
pharmacopeia traceability	traceable to BP 787, traceable to PhEur C2100000, traceable to USP 1131009
SMILES string	CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
InChI	1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
InChI key	QYSXJUFSXHHAJI-YRZJJWOYSA-N
Gene Information	human ... VDR(7421)

Pictograms	GHS06,GHS08
Signal Word	Danger
Hazard Statements	H300 + H310 + H330 - H372
Precautionary Statements	P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable