Rat / Mouse FGF-21 ELISA Kit

eCl@ss:	32161000
NACRES:	NA.32

Кат. номер

EZRMFGF21-26BK

EZRMFGF21-26K

Recent studies have demonstrated that fibroblast growth factor 21 (FGF-21), a liver derived protein, is able to increase glucose uptake, as well as lower plasma triglyceride levels in an insulin-independent manner. FGF-21 suppresses glucagon release, thereby increasing insulin sensitivity, and reduces the amount of insulin production by pancreatic -cells. Unlike insulin, which works in a rapid, hormone-like manner, FGF-21 activity requires several hours, indicating changes in gene expression. No significant weight gain was observed when FGF-21 was injected into animals, and mice that had been genetically engineered to overexpress FGF-21 weighed less and had less adipose tissue than the normal controls.
Although considerable progress has been made in the understanding of the pathobiology of type 2 diabetes, as well in the development of new compounds for the treatment of diabetic patients, this disease remains a major global health concern. Consequently, Millipore is pleased to offer the Rat/Mouse FGF-21 ELISA kit for the quantification of FGF-21 in rat and mouse serum and plasma samples. The insulin-independent activities of FGF-21, as well as the absence of the weight gain effects of insulin, thiazolidinediones and other anti-diabetic drugs, distinguish it from current insulin-sensitizing drugs, making it a promising therapeutic.
Specificity
Cross-reactivity to Human FGF-21: 39%
No significant cross-reactivity to the cytokines and metabolic hormones tested was observed.
Research Sub Category
Diabetes - Type 2
Metabolic Syndrome
Research Category
Metabolism
Used to detect/quantify: FGF-21
This is a 3-hour assay requiring 20 μL (in duplicate) of rat sample or 10µl (in duplicate) of mouse sample.
Please contact Technical Service for linearity of dilution.
Disclaimer
For research use only. Not for use in diagnostic procedures.

Quality Level	100,
species reactivity	rat, mouse
assay range	standard curve range: 50-12000 pg/mL, inter-assay cv: <8% intra-assay cv: <10%
application(s)	ELISA: suitable
detection method	colorimetric, fluorometric

pictograms	GHS05,GHS07,GHS09
signalword	Warning
pcodes	P273 - P280 - P302 + P352