MPLA (PHAD®)

Empirical Formula (Hill Notation):	C96H184N3O22P
CAS Number:	1246298-63-4
Molecular Weight:	1763.47
NACRES:	NA.25

Кат. номер

699800P-5MG

699800P-1MG

Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD®), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines.
Monophosphoryl lipid A (MPLA) is either extracted from bacterial lipid A or by chemical synthesis.
MPLA PHAD® has been used:

• as a component of cobalt porphyrin-phospholipid (Co-PoP) liposomes for the immunization of mice with membrane proximal external region (MPER) of the gp41 envelope protein
• as an adjuvant along with dimethyldioctadecylammonium bromide(DDA) for C. muridarum recombinant membrane protein based multi-subunit vaccine
• as toll-like receptor-4 (TLR4) agonist adjuvant for respiratory syncytial virus (RSV) fusion (F) protein FI-RSV vaccine

Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. MPLA used in vaccination improves B cell and T cell-mediated immunity.
2 mL Amber Glass Crimp Cap Vial (699800P-5mg)
2 mL Amber Glass Crimp Cap Vial (699800P-1mg)
For R&D use only. Not for drug, household, or other uses.
PHAD is a registered trademark of Avanti Polar Lipids, Inc.

assay	>99% (HPLC)
form	powder
packaging	pkg of 1 x 1 mg (699800P-1mg), pkg of 1 x 5 mg (699800P-5mg)
Торговая марка	Avanti Polar Lipids
shipped in	dry ice
storage temp.	20°C

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point F	Not applicable
Flash Point C	Not applicable